醫學檢驗暨生物技術學系YANG, AN-HANGAN-HANGYANGKAO, JAU-TSUENJAU-TSUENKAO2009-01-202018-07-062009-01-202018-07-061998http://ntur.lib.ntu.edu.tw//handle/246246/105253Two cases of lipoprotein glomerulopathy with a new apolipoprotein E (Apo E)genotype, epsilon3/epsilon4, were diagnosed recently. These 2 cases, together with other cases documented in English literature made a total of 6 common isoforms of Apo E encountered in lipoprotein glomerulopathy. Although the calculated allele frequency of epsilon2 is relatively high in cases with lipoprotein glomerulopathy as compared with that in the general population (39.3 vs. 6.4- 11.4%), the gradual emergence of Apo E isoforms other than E 2/E3 in lipoprotein glomerulopathy implicates that the genetic susceptibility of certain Apo E isoforms may not be a crucial factor. An alteration in the local environment of glomerular capillaries may be more important in the pathogenesis of lipoprotein glomerulopath.en-US