KUN-HUEI YEHHsieh H.-C.JIH-LUH TANGLin M.-T.CHIH-HSIN YANGYAO-CHANG CHEN2021-05-262021-05-2619940268-3369https://scholars.lib.ntu.edu.tw/handle/123456789/562989A 28-year-old man with chronic myelogenous leukaemia in blastic transformation underwent allogeneic bone marrow transplantation from his HLA-identical brother. Severe, progressive cholestatic jaundice developed from day 25 and did not respond to repeated therapy with high-dose methylprednisolone. In addition to marked cholestasis, both liver biopsy (day 69) and autopsy (day 134) findings revealed total disappearance of interlobular bile ducts in all of the portal areas, although extrahepatic manifestations of GVHD were minimal. Isolated acute vanishing bile duct syndrome can occur as the most severe form of acute hepatic GVHD.[SDGs]SDG3azathioprine; busulfan; cyclophosphamide; cyclosporin a; methotrexate; methylprednisolone; ursodeoxycholic acid; adult; allogenic bone marrow transplantation; article; autopsy; bile duct disease; blast transformation; case report; chronic myeloid leukemia; graft versus host reaction; human; human tissue; intravenous drug administration; leukopenia; liver biopsy; liver disease; male; obstructive jaundice; oral drug administration; priority journal; Acute Disease; Adult; Bile Duct Diseases; Bone Marrow Transplantation; Case Report; Graft vs Host Disease; Human; Leukemia, Myeloid, Chronic; Liver Diseases; Male; Support, Non-U.S. Gov't; Transplantation, Homologousjournal article79942492-s2.0-0027954040