Hsiao C.-H.KUN-HUEI YEHChang Y.-C.Tsai C.-C.2021-01-282021-01-2820130043-3144https://www.scopus.com/inward/record.uri?eid=2-s2.0-84907893763&partnerID=40&md5=40c5540c25a59e797bb3f6aa5a6206bchttps://scholars.lib.ntu.edu.tw/handle/123456789/543500Although breast cancer is, unfortunately, not uncommon in women, a mere 0.04% of malignant breast tumours are primary angiosarcomas. Chemotherapy is advocated for treatment of breast angiosarcomas; however, no guidelines exist regarding optimal chemotherapeutics or protocols. Presently, the prognosis for breast angiosarcomas is poor. This case report describes a 24-year old woman diagnosed with primary breast angiosarcoma. She initially refused to receive treatment, but later returned to the hospital four years later with a haemopneumothorax. She was treated with rescue chemotherapy using a combination of high-dose tamoxifen plus ifosfamide and epirubicin (an anthracycline). She achieved a partial response, but died 16 months after therapy was initiated. More research is needed to devise novel chemotherapeutics and protocols to improve outcomes in women diagnosed with primary angiosarcomas of the breast.Angioscarcoma; Anthracycline; Breast cancer; Chemotherapy; Ifosfamide; Tamoxifen[SDGs]SDG3blood clotting factor 8; CD31 antigen; cisplatin; epirubicin; ifosfamide; paclitaxel; tamoxifen; anthracycline; antineoplastic agent; ifosfamide; tamoxifen; adult; anemia; angiosarcoma; anorexia; Article; breast angiosarcoma; breast biopsy; breast self examination; breast tumor; cancer cell; cancer combination chemotherapy; case report; computer assisted tomography; continuous infusion; drug megadose; dyspnea; echography; female; flank pain; follow up; hematopneumothorax; hemostasis; human; mammography; muscle metastasis; neutropenia; pleura effusion; progression free survival; respiratory distress; survival time; thoracotomy; thrombocytopenia; vomiting; young adult; angiosarcoma; article; breast tumor; fatality; Anthracyclines; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Fatal Outcome; Female; Hemangiosarcoma; Humans; Ifosfamide; Tamoxifen; Young Adultjournal article248319062-s2.0-84907893763