張照夫2006-07-262018-07-092006-07-262018-07-091999http://ntur.lib.ntu.edu.tw//handle/246246/28676Salmonella choleraesuis是重要之豬細 菌性傳染病病原，引起養豬場重大經 濟損失。本計畫已由源自Salmonella致 病島-1 &-2( Salmonella pathogenicity island-2; SPI-1 &-2)之相關基因選殖出 8個部份基因群落(partial gene clone)。 SPI-1 &-2基因源自Salmonella choleraesuis & S. typhimurium。SPI-1 &-2基因群間有96-98％同質性。現正 以對偶基因交換(allelic exchange)技術 進行突變株產生．所有突變株以動物 試驗進行免疫性及病原性篩選。Salmonella choleraesuis is an important porcine bacterial pathogen, which causes an economic loss in swine industry. We have cloned partial genes derived from Salmonella pathogenicity island-1 &-2 (SPI-1 &-2). SPI-1 &-2 genes derived from Salmonella choleraesuis and S. typhimuriumshowing approximately 96- 98% identity. We are in process to construct SPI-1 &-2 mutant strains by allelic exchange, analyzing the immunological and pathological responses in animals.application/pdf36188 bytesapplication/pdfzh-TW國立臺灣大學獸醫學系暨研究所Salmonella choleraesuiscloningSalmonella pathogenicity island-1 &- 2 (SPI-1 &-2)[SDGs]SDG3reporthttp://ntur.lib.ntu.edu.tw/bitstream/246246/28676/1/882313B002116.pdf