Zinc supplementation augments the suppressive effects of repurposed NF-κB inhibitors on ACE2 expression in human lung cell lines

Lee, Ming-ChengMing-ChengLeeYIN-KAI CHENTsai-Wu, Jyy-JihJyy-JihTsai-WuHsu, Yih-JenYih-JenHsuBOR-RU LIN2023-06-132023-06-132021-09-010024-3205https://scholars.lib.ntu.edu.tw/handle/123456789/632651Angiotensin-converting enzyme 2 (ACE2) is a key negative regulator of the renin-angiotensin system and also a major receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Here, we reveal a role for NF-κB in human lung cell expression of ACE2, and we further explore the potential utility of repurposing NF-κB inhibitors to downregulate ACE2.enACE2; Emetine; NF-kappa B; ROS; Triclabendazole; ZincZinc supplementation augments the suppressive effects of repurposed NF-κB inhibitors on ACE2 expression in human lung cell linesjournal article10.1016/j.lfs.2021.119752341713822-s2.0-85109529220WOS:000671218400006https://api.elsevier.com/content/abstract/scopus_id/85109529220