職醫與工衛所TSENG, HSI-HUANGHSI-HUANGTSENGHWANG, YAW-HUEIYAW-HUEIHWANG2011-06-242018-06-292011-06-242018-06-292009http://ntur.lib.ntu.edu.tw//handle/246246/235890CCAAT/enhancer binding protein alpha (C/EBP alpha) is a transcription factor and a tumor suppressor. We aimed to assess its protein expression and prognostic value in human hepatocellular carcinoma (HCC). We conducted a retrospective cohort study on 50 HCC patients and performed immunohistochemistry against C/EBP alpha on tumors and adjacent nontumor specimens. Relationships of C/EBP alpha expression with clinical parameters and patient survival were analyzed. C/EBP alpha expression was not influenced by chronic alcohol exposure, viral hepatitis, or cirrhosis, but was reduced in 60% of HCC. Reduction of C/EBP alpha was associated with advanced tumor stage (P = 0.001). Patients with markedly reduced C/ EBP alpha expression had a significantly shorter survival with a hazard ratio of 5.45 ( 95% confidence interval, 1.93-15.40; P = 0.001). C/EBP alpha may be a potential prognostic marker or therapeutic target in HCC regardless of different etiology.en-USCCAAT/enhancer binding protein alphaImmunohistochemistryHepatocellular carcinomaSurvival[SDGs]SDG3journal article