C-C chemokine receptor 4 (CCR4)-positive regulatory T cells interact with tumor-associated macrophages to facilitate metastatic potential after radiation

YUN CHIANGLu, Li-FengLi-FengLuCHIAO-LING TSAIYU CHIEH TSAIWang, Chung-ChiehChung-ChiehWangFU-JEN HSUEHCHAO-YUAN HUANGCHUNG-HSIN CHENCHIA-HSIEN CHENGYEONG-SHIAU PU2024-02-212024-02-212024-12-0109598049https://scholars.lib.ntu.edu.tw/handle/123456789/639830Our previous study revealed that elevated C-C motif chemokine ligand 2 (CCL2) secretion by irradiated cancer cells recruited C-C motif chemokine receptor 2 (CCR2)-positive myeloid cells and polarized M2-type tumor-associated macrophages (TAMs), promoting lung metastasis in an established mouse model. This study investigated the impact of CCL2 and TAMs on adaptive immunity.enCCR4; Radiotherapy; Regulatory T cells; Tumor microenvironment; Tumor-associated macrophage[SDGs]SDG3C-C chemokine receptor 4 (CCR4)-positive regulatory T cells interact with tumor-associated macrophages to facilitate metastatic potential after radiationjournal article10.1016/j.ejca.2023.113521381711152-s2.0-85181712480https://scholars.lib.ntu.edu.tw/handle/123456789/639638