Wu Wen-ChauYA-FANG CHENTseng H.-M.Yang S.-C.My P.-C.2019-10-182019-10-1820150938-7994https://www.scopus.com/inward/record.uri?eid=2-s2.0-84937641290&doi=10.1007%2fs00330-015-3655-x&partnerID=40&md5=67772949f51f84fcfc3eff9d2a8020f0https://scholars.lib.ntu.edu.tw/handle/123456789/426867Objectives: To numerically and experimentally investigate the robustness of intravoxel incoherent motion (IVIM) magnetic resonance imaging in measuring perfusion indexes in the human brain. Methods: Eighteen healthy volunteers were imaged on a 3?T clinical system. Data of IVIM imaging (12 b-values ranging from 0 to 1000?s/mm2, 12 repetitions) were fitted with a bi-exponential model to extract blood volume fraction (f) and pseudo-diffusion coefficient (D*). The robustness of measurement was assessed by bootstrapping. Dynamic susceptibility contrast (DSC) imaging and arterial spin-labelling (ASL) imaging were performed for cross-modal comparison. Numerical simulations were performed to assess the accuracy and precision of f and D* estimates at varied signal-to-noise ratio (SNRb1000). Results: Based on our experimental setting (SNRb1000 ~ 30), the average error/variability is ~5?%/25?% for f and ~100?%/30?% for D* in gray matter, and ~10?%/50?% for f and ~300?%/60?% for D* in white matter. Correlation was found between f and DSC-derived cerebral blood volume in gray matter (r = 0.29 – 0.48 across subjects, p < 10-5), but not in white matter. No correlation was found between f-D*?product and ASL-derived cerebral blood flow. Conclusions: f may provide noninvasive measurement of cerebral blood volume, particularly in gray matter. D* has limited robustness and should be interpreted with caution. Key Points: ? A minimum SNRb1000of 30 is recommended for reliable IVIM imaging. ? f may provide noninvasive measurement of cerebral blood volume. ? f correlates with CBVDSCin gray matter. ? There is no correlation between fD* and CBFASL. ? D* has limited robustness and should be interpreted with caution. ? 2015, The Author(s).English[SDGs]SDG3adult; analytical error; arterial spin labelling imaging; Article; bootstrapping; brain blood flow; brain blood volume; brain perfusion; brain region; brain scintiscanning; clinical assessment; contrast enhancement; controlled study; dynamic susceptibility contrast imaging; female; gray matter; human; human experiment; image analysis; intravoxel incoherent motion imaging; male; measurement accuracy; neuroimaging; normal human; nuclear magnetic resonance imaging; nuclear magnetic resonance scanner; priority journal; radiofrequency; radiological parameters; signal noise ratio; spin labeling; white matter; brain; brain circulation; evaluation study; feasibility study; motion; nuclear magnetic resonance imaging; physiology; procedures; prospective study; theoretical model; vascularization; young adult; Adult; Brain; Cerebrovascular Circulation; Feasibility Studies; Female; Gray Matter; Healthy Volunteers; Humans; Magnetic Resonance Imaging; Male; Models, Theoretical; Motion; Prospective Studies; Signal-To-Noise Ratio; Young Adultjournal article10.1007/s00330-015-3655-x256936682-s2.0-84937641290