Teng, Ling-LingLing-LingTengLu, Guan-LingGuan-LingLuLIH-CHU CHIOULin, Wei-ShengWei-ShengLinCheng, Ya-YunYa-YunChengHsueh, Tai-EnTai-EnHsuehHuang, Yi-ChingYi-ChingHuangHwang, Nai-HsuanNai-HsuanHwangYeh, Jin-WeiJin-WeiYehLiao, Ruey-MingRuey-MingLiaoSHOU-ZEN FANYen, Jui-HungJui-HungYenFu, Tsai-FengTsai-FengFuTsai, Ting-FenTing-FenTsaiMING-SHIANG WUPEI-YU WANG2023-12-122023-12-122019-0315449173https://scholars.lib.ntu.edu.tw/handle/123456789/637697Dietary restriction (DR; sometimes called calorie restriction) has profound beneficial effects on physiological, psychological, and behavioral outcomes in animals and in humans. We have explored the molecular mechanism of DR-induced memory enhancement and demonstrate that dietary tryptophan-a precursor amino acid for serotonin biosynthesis in the brain-and serotonin receptor 5-hydroxytryptamine receptor 6 (HTR6) are crucial in mediating this process. We show that HTR6 inactivation diminishes DR-induced neurological alterations, including reduced dendritic complexity, increased spine density, and enhanced long-term potentiation (LTP) in hippocampal neurons. Moreover, we find that HTR6-mediated mechanistic target of rapamycin complex 1 (mTORC1) signaling is involved in DR-induced memory improvement. Our results suggest that the HTR6-mediated mTORC1 pathway may function as a nutrient sensor in hippocampal neurons to couple memory performance to dietary intake.en[SDGs]SDG3journal article10.1371/journal.pbio.2007097308835472-s2.0-85064144844https://scholars.lib.ntu.edu.tw/handle/123456789/424651