Lin C.-Y.Lee H.-L.Sung F.-C.TA-CHEN SU2020-09-282020-09-2820180269-7491https://www.scopus.com/inward/record.uri?eid=2-s2.0-85045770207&doi=10.1016%2fj.envpol.2018.04.010&partnerID=40&md5=fbd97829dd36ef8d5257f8a22788713dhttps://scholars.lib.ntu.edu.tw/handle/123456789/514747Acrylonitrile is a colorless volatile liquid mostly present in tobacco smoke. Acrylonitrile exposure has shown to increase oxidative stress in animal studies; however, there was no previous research in human epidemiology. In this study, 853 subjects were recruited from a cohort of Taiwanese adolescents and young adults to investigate the association between urinary concentrations of the acrylonitrile metabolite N-acetyl-S-(2-cyanoethyl)-L-cysteine (CEMA), the oxidative stress product 8-hydroxydeoxyguanosine (8-OHdG) and cardiovascular disease (CVD) risk factors. The geometric mean (SD) of CEMA and 8-OHdG concentrations were 4.67 (8.61) μg/L and 2.97 (2.14) μg/L, respectively. 10% elevated in CEMA (μg/L) was positively correlated with the change of 8-OHdG levels (μg/L) (β = 0.325, SE = 0.105, P = 0.002) in multiple linear regression analyses. The urinary CEMA was not related to other CVD risk factors. In subpopulation analyses, the association between CEMA and 8-OHdG was evident in all genders, adolescents, homeostasis model assessment of insulin resistance score ?0.89, and environmental tobacco smokers. In this study, we observed that higher levels of CEMA levels were correlated with increased levels of 8-OHdG in this cohort. Future research on exposure to acrylonitrile and oxidative stress was warranted. Acrylonitrile metabolite n-acetyl-s-(2-cyanoethyl)-L-cysteine were positively associated with increased levels of 8-OHdG in this cohort of adolescents and young adults. ? 2018 Elsevier Ltd[SDGs]SDG3Amino acids; Biomolecules; Linear regression; Metabolites; Tobacco; 8-HydroxyDeoxyguanosine (8-OHdG); Acrylonitrile; Cardiovascular disease; Homeostasis model assessments; Insulin resistance; L-cysteine; Multiple linear regression analysis; Volatile liquids; Oxidative stress; 8 hydroxydeoxyguanosine; acrylonitrile; biological marker; n acetyl s (2 cyanoethyl)cysteine; unclassified drug; 8-oxo-7-hydrodeoxyguanosine; acetylcysteine; acrylonitrile; biological marker; deoxyguanosine; N-acetyl-S-(2-cyanoethyl)cysteine; concentration (composition); epidemiology; metabolite; oxidative stress; regression analysis; research work; risk factor; urine; young population; adolescent; adult; Article; cardiovascular disease; cardiovascular risk; child; clinical assessment; cohort analysis; concentration (parameters); controlled study; correlational study; cross-sectional study; environmental exposure; female; household income; human; insulin resistance; male; multiple linear regression analysis; oxidative stress; smoking; urine level; analogs and derivatives; Asian continental ancestry group; metabolism; oxidative stress; physiology; statistics and numerical data; urine; young adult; Taiwan; Animalia; Nicotiana tabacum; Acetylcysteine; Acrylonitrile; Adolescent; Adult; Asian Continental Ancestry Group; Biomarkers; Deoxyguanosine; Environmental Exposure; Female; Humans; Male; Oxidative Stress; Smoking; Young Adultjournal article10.1016/j.envpol.2018.04.010296848762-s2.0-85045770207