Ou, Anna HAnna HOuRosenthal, Sara BSara BRosenthalAdli, MazdaMazdaAdliAkiyama, KazufumiKazufumiAkiyamaAkula, NirmalaNirmalaAkulaAlda, MartinMartinAldaAmare, Azmeraw TAzmeraw TAmareArdau, RaffaellaRaffaellaArdauArias, BárbaraBárbaraAriasAubry, Jean-MichelJean-MichelAubryBacklund, LenaLenaBacklundBauer, MichaelMichaelBauerBaune, Bernhard TBernhard TBauneBellivier, FrankFrankBellivierBenabarre, AntonioAntonioBenabarreBengesser, SusanneSusanneBengesserBhattacharjee, Abesh KumarAbesh KumarBhattacharjeeBiernacka, Joanna MJoanna MBiernackaCervantes, PabloPabloCervantesChen, Guo-BoGuo-BoChenHSI-CHUNG CHENChillotti, CaterinaCaterinaChillottiCichon, SvenSvenCichonClark, Scott RScott RClarkColom, FrancescFrancescColomCousins, David ADavid ACousinsCruceanu, CristianaCristianaCruceanuCzerski, Piotr MPiotr MCzerskiDantas, Clarissa RClarissa RDantasDayer, AlexandreAlexandreDayerDel Zompo, MariaMariaDel ZompoDegenhardt, FranziskaFranziskaDegenhardtDePaulo, J RaymondJ RaymondDePauloÉtain, BrunoBrunoÉtainFalkai, PeterPeterFalkaiFellendorf, Frederike TabeaFrederike TabeaFellendorfFerensztajn-Rochowiak, EwaEwaFerensztajn-RochowiakForstner, Andreas JAndreas JForstnerFrisén, LouiseLouiseFrisénFrye, Mark AMark AFryeFullerton, Janice MJanice MFullertonGard, SébastienSébastienGardGarnham, Julie SJulie SGarnhamGoes, Fernando SFernando SGoesGrigoroiu-Serbanescu, MariaMariaGrigoroiu-SerbanescuGrof, PaulPaulGrofGruber, OliverOliverGruberHashimoto, RyotaRyotaHashimotoHauser, JoannaJoannaHauserHeilbronner, UrsUrsHeilbronnerHerms, StefanStefanHermsHoffmann, PerPerHoffmannHofmann, AndreaAndreaHofmannHou, LipingLipingHouJamain, StephaneStephaneJamainJiménez, EstherEstherJiménezKahn, Jean-PierreJean-PierreKahnKassem, LaylaLaylaKassemKato, TadafumiTadafumiKatoKittel-Schneider, SarahSarahKittel-SchneiderKönig, BarbaraBarbaraKönigPO-HSIU KUOKusumi, IchiroIchiroKusumiLackner, NinaNinaLacknerLaje, GonzaloGonzaloLajeLandén, MikaelMikaelLandénLavebratt, CatharinaCatharinaLavebrattLeboyer, MarionMarionLeboyerLeckband, Susan GSusan GLeckbandJaramillo, Carlos A LópezCarlos A LópezJaramilloMacQueen, GlendaGlendaMacQueenMaj, MarioMarioMajManchia, MirkoMirkoManchiaMarie-Claire, CynthiaCynthiaMarie-ClaireMartinsson, LinaLinaMartinssonMattheisen, ManuelManuelMattheisenMcCarthy, Michael JMichael JMcCarthyMcElroy, Susan LSusan LMcElroyMcMahon, Francis JFrancis JMcMahonMitchell, Philip BPhilip BMitchellMitjans, MarinaMarinaMitjansMondimore, Francis MFrancis MMondimoreMonteleone, PalmieroPalmieroMonteleoneNievergelt, Caroline MCaroline MNievergeltNöthen, Markus MMarkus MNöthenNovák, TomasTomasNovákÖsby, UrbanUrbanÖsbyOzaki, NorioNorioOzakiPapiol, SergiSergiPapiolPerlis, Roy HRoy HPerlisPisanu, ClaudiaClaudiaPisanuPotash, James BJames BPotashPfennig, AndreaAndreaPfennigReich-Erkelenz, DanielaDanielaReich-ErkelenzReif, AndreasAndreasReifReininghaus, Eva ZEva ZReininghausRietschel, MarcellaMarcellaRietschelRouleau, Guy AGuy ARouleauRybakowski, Janusz KJanusz KRybakowskiSchalling, MartinMartinSchallingSchofield, Peter RPeter RSchofieldSchubert, K OliverK OliverSchubertSchulze, Thomas GThomas GSchulzeSchweizer, Barbara WBarbara WSchweizerSeemüller, FlorianFlorianSeemüllerSeverino, GiovanniGiovanniSeverinoShekhtman, TatyanaTatyanaShekhtmanShilling, Paul DPaul DShillingShimoda, KazutakaKazutakaShimodaSimhandl, ChristianChristianSimhandlSlaney, Claire MClaire MSlaneySquassina, AlessioAlessioSquassinaStamm, ThomasThomasStammStopkova, PavlaPavlaStopkovaTighe, Sarah KSarah KTigheTortorella, AlfonsoAlfonsoTortorellaTurecki, GustavoGustavoTureckiVieta, EduardEduardVietaVolkert, JuliaJuliaVolkertWitt, StephanieStephanieWittWray, Naomi RNaomi RWrayWright, AdamAdamWrightYoung, L TrevorL TrevorYoungZandi, Peter PPeter PZandiKelsoe, John RJohn RKelsoe2024-03-062024-03-062024-122158-3188https://scholars.lib.ntu.edu.tw/handle/123456789/640440Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action is incompletely understood, and prediction of treatment outcomes is limited. In our previous multi-omics study of the Pharmacogenomics of Bipolar Disorder (PGBD) sample combining transcriptomic and genomic data, we found that focal adhesion, the extracellular matrix (ECM), and PI3K-Akt signaling networks were associated with response to lithium. In this study, we replicated the results of our previous study using network propagation methods in a genome-wide association study of an independent sample of 2039 patients from the International Consortium on Lithium Genetics (ConLiGen) study. We identified functional enrichment in focal adhesion and PI3K-Akt pathways, but we did not find an association with the ECM pathway. Our results suggest that deficits in the neuronal growth cone and PI3K-Akt signaling, but not in ECM proteins, may influence response to lithium in BD.en[SDGs]SDG3[SDGs]SDG17journal article10.1038/s41398-024-02811-4383959062-s2.0-85185915765https://api.elsevier.com/content/abstract/scopus_id/85185915765