Tseng, Yu-JuYu-JuTsengTai, Chih-HsunChih-HsunTaiGUAN-YUAN CHENYEN-LIN CHENSHIH-CHI KUPai, Tsung-YuTsung-YuPaiWu, Chien-ChihChien-ChihWu2025-05-092025-05-09202520420986https://scholars.lib.ntu.edu.tw/handle/123456789/729188Background: Patients with low body weight (LBW) often exhibit altered pharmacokinetics (PK) in renal clearance and total body water. These changes complicate β-lactam antibiotic dosing, potentially resulting in suboptimal efficacy or increased toxicity. Objectives: To evaluate the attainment of PK/pharmacodynamic (PD) targets, the prevalence of subtherapeutic and supratherapeutic concentrations, and the incidence of neurotoxicity among LBW patients treated with piperacillin/tazobactam (TZP), cefepime (FEP), and meropenem (MEM). Design: A prospective observational study conducted at a tertiary hospital from January 2020 to December 2022. Methods: Adult patients with a body mass index ⩽18.5 kg/m2 who received TZP, FEP, or MEM were included. Trough serum concentrations were analyzed for PK/PD targets: 100% time above minimum inhibitory concentration (100% fT > MIC) and 100% time above four times MIC (100% fT > 4MIC). Neurotoxicity was assessed using standardized criteria. Statistical analyses identified factors associated with concentration variability and adverse outcomes. Results: Seventy-two patients were included: 29 received TZP, 23 FEP, and 20 MEM. Achievement of the 100% fT > MIC target was comparable across all antibiotics (~70%), but 100% fT > 4 MIC attainment was significantly higher for FEP (47.8%) than for TZP (10.3%) and MEM (30%) (p = 0.01). Supratherapeutic concentrations were observed in 34.8% of FEP users compared to 3.4% and 5% for TZP and MEM, respectively (p = 0.002). Neurotoxicity occurred in 13% of FEP patients but was not reported in TZP or MEM groups (p = 0.04). Subtherapeutic concentrations were noted in approximately 30% of patients across all groups. Conclusion: PK changes complicate β-lactam antibiotic dosing, resulting in frequent failure to achieve PK/PD targets. FEP demonstrated a particularly high risk of supratherapeutic concentrations and neurotoxicity. Therapeutic drug monitoring is crucial to optimize dosing and improve safety in this population.entruelow body weightpharmacokinetics/pharmacodynamicstherapeutic drug monitoringβ-lactam antibiotics[SDGs]SDG3[SDGs]SDG6journal article10.1177/20420986251320414399742812-s2.0-105000232894