Hsu C.Y.Hsiao J.P.MING-JIUM SHIEHLai P.S.2020-02-272020-02-272011https://www.scopus.com/inward/record.uri?eid=2-s2.0-81455139921&partnerID=40&md5=31f68f54a48d21ae1e1669c5cc8d495ahttps://scholars.lib.ntu.edu.tw/handle/123456789/465768An annoying problem of chemotherapy is the drug resistance of cancer cells which express of multidrug-resistance associated proteins and thereby resulting in ineffective treatment. To conquer this problem, tri-block copolymer, polyethylene glycol-polycaprolactone-polyethylenimine forming micelle was utilized to encapsulate the chemotherapeutic drug, paclitaxel (PTX), in the core of micelle and to attract the small interfering RNA (siRNA) on the corona of micelle and to make drug resistance cancer cell sensitizing to chemotherapeutic drug. Gratifyingly, dual agents (PTX and siRNA) combination polymeric micelles were showed to increase the intracellular accumulation of paclitaxel and were observed to kill doxorubicin resistant (MCF-7 ADR) cells by silencing the expression of multidrug-resistance associated proteins, P-glycoprotein. This result suggested that the tri-block polymeric micelle as a potential carrier for gene and chemotherapy against the multidrug-resistance cancer cell.Chemotherapy; Gene therapy; Micelle; Multidrug-resistance[SDGs]SDG3Cancer cells; Chemotherapeutic drugs; Doxorubicin; Drug resistance; Intracellular accumulation; Multidrug-resistance; P-glycoprotein; Paclitaxel; Polymeric micelle; Small interfering rna (siRNA); Block copolymers; Cells; Chemotherapy; Diseases; Fluidics; Functional polymers; Glycols; Glycoproteins; Medical nanotechnology; Micelles; Nanotechnology; Pharmacodynamics; Polycaprolactone; Polyethylene glycols; RNA; Gene therapyconference paper2-s2.0-81455139921