婦產科LIN, HO-HSIUNGHO-HSIUNGLINSU, YI-NINGYI-NINGSUWEI, LIN- HUNGLIN- HUNGWEIHUANG, SU-CHENGSU-CHENGHUANG林鶴雄蘇怡寧魏凌鴻黃思誠2008-12-242018-07-122008-12-242018-07-121997http://ntur.lib.ntu.edu.tw//handle/246246/93845Objective: To compare the efficacy of puerperal lactation suppression by metergoline versus bro-mocriptine. Methods: A prospective, randomized clinical trial of patients with puerperal lactation suppression. Eighty- three parturients were recruited and randomly divided into 4 groups. Group A1 consisted of 24 normal spontaneous delivery cases treated by metergoline and group A2 was 18 cesarean de-livery cases treated by metergoline. Another 23 normal spontaneous delivery cases (group B1) and 18 cesarean delivery cases ( group B2) were treated by bromocriptine. The clinical assessment dur-ing and after medication included the status of inhibition of breast milk secretion, breast engorge-ment and pain as well as the presence of side-effects. In addition, paired serum samples of prolac-tin levels before medication and the third day after medication ( the day of discharge) were meas-ured and the suppression rate of the prolactin level in each case was determined. Results: The mean age, parity and pre-treatment p rolactin level were not statistically significant among the four groups. In contrast, the suppression rate of the prolactin level by bromocriptine was statistically greater than that by metergoline (89% vs. 83%, p< 0.05). However, the clinical as -sessment of lactation inhibition was excellent in each case , and no patients showed any obvious side-effects during follow-up. Conclusions: Both drugs were effective in puerperal lactation suppression and clinical assess-ment of their lactation inhibition was good.en-US