KUO-LIONG CHIENMING-FONG CHENHsu, Hsiu-ChingHsiu-ChingHsuTA-CHEN SUWEI-TIEN CHANGCHII-MING LEELee, Yuan-TehYuan-TehLee2020-03-122020-03-122008-020009-8981https://scholars.lib.ntu.edu.tw/handle/123456789/475884https://www.scopus.com/record/display.uri?eid=2-s2.0-37249076490&doi=10.1016%2fj.cca.2007.10.006&origin=inward&txGid=4d7af385d3c5d7cf5d75e19d810cdf0aBackground: Polymorphism of apolipoprotein A1/C3/A4/A5 gene cluster affected lipid profiles in general population. We reported 6 polymorphisms, APOA1 -75G>A, APOA1 83C>T, APOC3 3175C>G, APOC3 3206G>T, APOA4 127A>G, and APOA5 553G>T in APOA1/C3/A4/A5 gene and the haplotype structures on triglyceride and HDL traits among ethnic Chinese. Results: Overall, there were statistically significant differences in the distribution of APOA1 -75G>A and APOA5 +553G>T genotypes comparing cases with control subjects. For the APOA1 -75 SNP, a lower risk of triglyceride/HDL among subjects with A/A genotype compared with those with the G/G genotype (odds ratio, OR = 0.39, 95% CI 0.16-0.92, P = 0.04). However, the risk magnitude reduced after multivariate adjustments. For continuous traits, we found that only in APOA5 +553 T allele carriers showed a significant higher triglyceride and a significant lower HDL cholesterol level than subjects with APOA5 +553 G/G genotypes. There were significant differences in overall haplotype frequencies between case and control subjects (P < 0.001). Conclusion: There is an important role of APOA1/C3/A4/A5 gene polymorphisms and haplotypes in the development of high triglyceride/HDL ratio in Chinese. © 2007.enApolipoprotein A1/C3/A4/A5; Haplotype; HDL cholesterol; Triglyceridejournal article10.1016/j.cca.2007.10.006179642932-s2.0-37249076490