Yang S.-Y.Weng P.-H.JEN-HAU CHENJENG-MIN CHIOULew-Ting C.-Y.TA-FU CHENSun Y.Wen L.-L.Yip P.-K.Chu Y.-M.YEN-CHING CHEN2020-11-032020-11-0320150929-6646https://www.scopus.com/inward/record.uri?eid=2-s2.0-85000096302&doi=10.1016%2fj.jfma.2014.09.006&partnerID=40&md5=a08062d20bd9e23d1d089158419f9d53https://scholars.lib.ntu.edu.tw/handle/123456789/519476Background/Purpose: Leisure activities have been associated with a decreased risk of dementia. However, to date, no study has explored how apolipoprotein E (. ApoE) e4 status or vascular risk factors modified the association between leisure activities and dementia risks. Methods: This case-control study recruited patients (age ? 60 years) with Alzheimer's disease (AD; n = 292) and vascular dementia (VaD; n = 144) and healthy controls (. n = 506) from three teaching hospitals in Taiwan between 2007 and 2010. Information on patient's leisure activities were obtained through a questionnaire. Conditional logistic regression models were used to assess the association of leisure activities and ApoE e4 status with the risk of dementia. Results: High-frequency physical activity was associated with a decreased risk of AD [adjusted odds ratio (AOR) = 0.45], and the results become more evident among ApoE e4 carriers with AD (AOR = 0.30) and VaD (AOR = 0.26). Similar findings were observed for cognitive (AOR = 0.42) and social activities (AOR = 0.55) for AD. High-frequency physical, cognitive, and social activities were associated with a decreased risk of VaD (AOR = 0.29-0.60). Physical and social activities significantly interacted with each other on the risk of VaD (pinteraction = 0.04). Conclusion: Physical activity consistently protects against AD and VaD. Significant interactions were identified across different types of leisure activities in lowering dementia risk. ? 2014.[SDGs]SDG3apolipoprotein E4; apolipoprotein E4; genetic marker; aged; Alzheimer disease; Article; controlled study; female; human; leisure; major clinical study; male; multiinfarct dementia; physical activity; risk factor; social behavior; Taiwan; Alzheimer disease; case control study; clinical trial; genetic marker; genetics; heterozygote; motor activity; multicenter study; odds ratio; questionnaire; statistical model; very elderly; Aged; Aged, 80 and over; Alzheimer Disease; Apolipoprotein E4; Case-Control Studies; Female; Genetic Markers; Heterozygote; Humans; Leisure Activities; Logistic Models; Male; Motor Activity; Odds Ratio; Risk Factors; Surveys and Questionnaires; Taiwanjournal article10.1016/j.jfma.2014.09.006254572932-s2.0-85000096302