Lin, W.-Y.W.-Y.LinLu, Y.Y.LuSu, J.-H.J.-H.SuWen, Z.-H.Z.-H.WenCHANG-FENG DAIKuo, Y.-H.Y.-H.KuoSheu, J.-H.J.-H.Sheu2018-09-102018-09-102011http://www.scopus.com/inward/record.url?eid=2-s2.0-79959750983&partnerID=MN8TOARShttp://scholars.lib.ntu.edu.tw/handle/123456789/363594Seven new cembranoids, sarcocrassocolides F-L (1-7), have been isolated from a soft coral Sarcophyton crassocaule. Their structures were determined by extensive spectroscopic analysis. Most new compounds exhibited significant cytotoxic activity against a limited panel of cancer cell lines, and the structure-activity relationship was studied. Compounds 1-7 were found to display significant in vitro anti-inflammatory activity in LPS-stimulated RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein. Compound 4 was also found to effectively reduce the level of COX-2 protein. ? 2011 by the authors.Anti-inflammatory activity; Cytotoxic activity; Sarcophyton crassocaule; Soft coral[SDGs]SDG3[SDGs]SDG14cembranoid; cyclooxygenase 2; inducible nitric oxide synthase; mitomycin C; sarcocrassocolide F; sarcocrassocolide G; sarcocrassocolide H; sarcocrassocolide I; sarcocrassocolide J; sarcocrassocolide K; sarcocrassocolide L; unclassified drug; antiinflammatory activity; article; cancer cell culture; controlled study; coral; drug cytotoxicity; drug isolation; drug structure; human; human cell; in vitro study; macrophage; nonhuman; protein expression; Sarcophyton crassocaule; structure activity relation; Alcyonacea; Sarcophyton crassocaulejournal article10.3390/md90609942-s2.0-79959750983WOS:000292632600007