2017-08-012024-05-17https://scholars.lib.ntu.edu.tw/handle/123456789/692876摘要：聚胺酯(PU)類材料具有優異的彈性與生物相容性，可經由分子設計使其具有雙性鏈段而在水相中 自乳化聚合而成水性聚胺酯，亦可選用可分解的軟鏈段製備水性生物可降解性聚胺酯(waterborne biodegradable polyurethane, WBDPU)，其生物分解特性與水性製程有利於生物醫學之應用。目前我們 已初步合成出具有溫度感應及形狀記憶特性之PU材料，然而因生醫領域需更仿生及具智慧性之材料以 增加生物相容性與功能性，我們希望結合過去PU合成與生醫材料開發之經驗，結合水性加工技術進行 成型，設計出適合人體應用之智慧性WBDPU。由於前次三年期計畫僅核准第一年之經費，因此，本 年度重新將成果整理，繼續申請另一個二年期計畫。此次繼續提出之二年期計畫擬建立新穎WBDPU 之成膠機制與形狀記憶機制，並將智慧性之WBDPU結合水性加工技術應用於生醫領域。第一年重點 在調整可降解聚酯軟鏈段的種類及組合比例，合成環境感應性之WBDPU水膠與形狀記憶之WBDPU， 透過交叉分析各種不同配方之環境感應性WBDPU水膠與形狀記憶WBDPU物化性結果，彙整WBDPU 形狀記憶效應產生以及誘發環境感應性WBDPU水膠形成可能之原因。並初步將智慧型WBDPU結合水 性加工技術成型，評估不同智慧型WBDPU對幹細胞之影響。第二年重點在優化水膠與形狀記憶材料 合成配方、參數與水性加工技術，建立其成型機制與作用原理。並進行智慧性WBDPU支架之動物實 驗，驗證其在神經修復與軟骨修復之功能性。透過此二年所建立的物化特性與體內外實驗等分析結 果，瞭解WBDPU智慧性之調控機制與設計準則，並建立應用於神經修復與軟骨在生之最適化原料配 方。<br> Abstract: Polyurethanes are commonly used as biomaterials due to their good biocompatibility and elastomeric properties. In recent years, waterborne biodegradable polyurethanes (WBDPU) have been synthesized by biodegradable soft segments and water process. The biodegradability and water processing of WBDPU can be advantageous for biomedical applications. Our recent studies have indicated that some synthetic WBDPU showed the temperature responsive gelling behavior or shape memory properties. These unique characteristics of WBDPU materials are beneficial for biomedical applications. We hope to utilize our development experiences of WBDPU and water process to design a category of smart materials that are suitable for use in the human body. With the results of recent data, we propose this two-year project to develop the smart WBDPU hydrogel. We will summarize the mechanism for thermal responsive hydrogel formation and shape memory properties in WBDPU. Furthermore, we will combine smart WBDPU and water process technology for biomedical applications. In the first year, we will focus on preparation of smart WBDPU with thermal responsive hydrogel and shape memory properties. The formation mechanism analysis of thermal responsive hydrogel and shape memory properties in WBDPU, including the preparation of various smart WBDPU synthesis by regulation of the ester component in soft segment, physico-chemical characterization, biocompatibility and degradation evaluation, as well as rheological measurement and shape memory testing. In the second year, we will concentrate on optimization of the WBDPU formulae for temperature responsive hydrogels and shape memory elastomers. The mechanisms for hydrogel formation and shape memory properties in WBDPU will be established. Afterwards, we will analyze the functional properties of the WBDPU scaffolds for neural repair and cartilage regeneration in vivo. Through this two-year project, we will summarize various hydrogel forming and shape memory mechanisms to optimize WBDPU preparation for a wide range of biomedical applications.水性生物可降解聚胺酯環境感應性水膠形狀記憶彈性體智慧性材料