Giorgi J.VHONG-NERNG HOHirji KChou C.-CHultin L.ERourke S O'Park LMargolick J.BFerbas JPhair J.PSaah A.JArmenian HFarzadegan HGraham NMc Arthur JMargolick J.BPalenicek JMuãoz AHoover DGalai NJacobson L.PPark LPiantadosi SSu SPhair J.PBauer KChmiel J.SCohen BVariakojis DWesch JWolinsky S.MDetels RVisscher B.RChen IDudley JFahey J.LFerbas JGiorgi J.VMartinez-Maza ONishanian PTaylor JZack JRinaldo C.RJrBecker J.TGupta PHo MKingsley LSchrager LKaslow R.AVan Raden M.JSeminara D.2020-02-172020-02-1719940022-1899https://scholars.lib.ntu.edu.tw/handle/123456789/460198Subsets of activated CD8+ lymphocytes defined by membrane expression of the activation antigens HLA-DR and CD38 were counted by three-color flow cytometry in homosexual men who subsequently became seropositive for human immunodeficiency virus type 1 (HIV). Profound CD8+ cell activation was seen in all subjects at seroconversion and 6 and 12 months later. The HLA-DR+ CD38+ CD8+ cell population, which has potent direct HIV cytotoxic T cell activity, was markedly elevated at seroconversion in all subjects. In some men, these levels remained elevated throughout the first year of infection. During the next 5 years, these men had stable CD4+ cell levels, whereas the others did not. Long-term survivors (seropositive for 9 years, >800 CD4+ cells/mm3) also had elevated levels of this subset, despite few other activated CD8+ cells. Thus, selective elevation of HLA-DR+ CD38 CD8+ cells was a marker of subsequent stable HIV disease. ? 1994 by The University of Chicago.[SDGs]SDG3cd38 antigen; cd4 antigen; cd8 antigen; HLA DR antigen; lymphocyte antigen; adult; article; clinical article; controlled study; cytotoxic t lymphocyte; flow cytometry; helper cell; homosexuality; human; human cell; human immunodeficiency virus 1; human immunodeficiency virus infection; lymphocyte activation; male; priority journal; seroconversion; suppressor cell; Antigens, CD; Antigens, Differentiation; Bisexuality; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Flow Cytometry; Follow-Up Studies; HIV Seronegativity; HIV Seropositivity; HLA-DR Antigens; Homosexuality, Male; Human; Lymphocyte Activation; Male; Predictive Value of Tests; Reference Values; Support, U.S. Gov't, P.H.S.; Survival Analysis; T-Lymphocyte Subsets; Time Factorsjournal article10.1093/infdis/170.4.77579307172-s2.0-0027965585