SHUENN-NAN CHIUPEI-LAN SHAOChen H.-C.MING-TAI LINLI-MIN HUANGKao F.-Y.Huang S.-K.JOU-KOU WANGMEI-HWAN WU2020-12-212020-12-2120160022-3476https://www.scopus.com/inward/record.uri?eid=2-s2.0-84955559152&doi=10.1016%2fj.jpeds.2015.12.029&partnerID=40&md5=9e47d9940bfc2695d3c77a9fe544304chttps://scholars.lib.ntu.edu.tw/handle/123456789/529280Objective To compare the risk of respiratory syncytial virus (RSV)-associated hospitalization and analyze the epidemiology of RSV infection in patients with cyanotic and acyanotic congenital heart disease (CHD), we analyzed the nationwide health insurance database from 2005-2010. Study design This study included 1050 patients with cyanotic CHD and 7077 patients with acyanotic CHD. Patients with acyanotic CHD were further classified into hemodynamically significant (hs)-acyanotic and non-hs-acyanotic groups according to whether they underwent surgery or took at least 2 anticongestive medications. Results RSV-associated hospitalization was higher in the cyanotic group than in hs-acyanotic and non-hs-acyanotic groups both before 1 year of age (4.8% vs 2.1% vs 1.5%, P <.001) and between 1 and 2 years of age (0.9% vs 0.56% vs 0.14%, P =.003). The hospitalization duration, intensive care, ventilator support prevalence, hospitalization cost, and mortality rate were significantly higher in the cyanotic group than in the other 2 groups. Logistic regression revealed that cyanotic CHD was the most significant risk factor for the ventilator support and RSV-associated mortality. In both patients with cyanotic and acyanotic CHD, RSV-associated hospitalization rate was higher in patients aged younger than 1 year and in spring and autumn in Taiwan, a subtropical country. Conclusions The results show that patients with cyanotic CHD have a higher risk of severe RSV infection than do those with acyanotic CHD. RSV prophylaxis is more important and may reduce costs more for patients with cyanotic CHD. ? 2016 Elsevier Inc.[SDGs]SDG3acyanotic congenital heart disease; Article; autumn; child; chromosome aberration; comparative study; congenital heart disease; controlled study; cyanotic congenital heart disease; cyanotic heart disease; data base; disease severity; female; health insurance; hospitalization cost; human; ICD-9-CM; infant; infection risk; intensive care; length of stay; major clinical study; male; mortality rate; newborn; prematurity; prevalence; priority journal; respiratory syncytial virus infection; risk factor; sex difference; sex ratio; spring; Taiwan; complication; cyanosis; factual database; Heart Defects, Congenital; hemodynamics; hospitalization; Human respiratory syncytial virus; incidence; register; Respiratory Syncytial Virus Infections; risk; season; antivirus agent; palivizumab; Antiviral Agents; Cyanosis; Databases, Factual; Female; Heart Defects, Congenital; Hemodynamics; Hospitalization; Humans; Incidence; Infant; Infant, Newborn; Insurance, Health; Male; Palivizumab; Registries; Respiratory Syncytial Virus Infections; Respiratory Syncytial Viruses; Risk; Seasons; Taiwanjournal article10.1016/j.jpeds.2015.12.029268226182-s2.0-84955559152