CHIA-TER CHAOSZU-YING LEEWEI-SHUN YANGCHUNG-JEN YENCHIH-KANG CHIANGJENQ-WEN HUANGKUAN-YU HUNG2020-10-142020-10-1420142045-2322https://www.scopus.com/inward/record.uri?eid=2-s2.0-84923290104&doi=10.1038%2fsrep07371&partnerID=40&md5=aaedd85b553007fdc671ddd68e54e650https://scholars.lib.ntu.edu.tw/handle/123456789/516899Uremia results in a relatively immunocompromised status, and patients under chronic dialysis have an elevated risk of developing herpes zoster (HZ). We sought to investigate the relationship between vitamin D status and immunity to varicella-zoster virus (VZV). A multicenter prevalent hemodialysis cohort was assembled between 2012 and 2013. We assayed the biochemical parameters, 25-hydroxy- (25-OH-D) and 1,25-dihydroxyvitamin D, vitamin D-binding protein levels in the sera. VZV immunity was quantitated using VZV-specific glycoprotein IgG and IgM titers. Eighty-eight patients were enrolled and their sera were analyzed. Chronic hemodialysis patients with 25-OH-D < 30 ng/ml (insufficiency or deficiency) had significantly lower VZV-IgG than those with sufficient 25-OH-D (p = 0.04). This discrepancy became more prominent if active vitamin D users alone were analyzed (p = 0.01). Generalized additive modeling showed that those with 25-OH-D higher than 27.8 ng/ml or bioavailable 25-OH-D higher than 3.88 ng/ml had significantly higher VZV-IgG levels than those with lower values. Linear regression suggested that both total and bioavailable 25-OH-D were significantly associated with higher VZV-IgG levels (p = 0.003 [total] and 0.01 [bioavailable]), whereas patients with cancer had lower VZV-IgG. Vitamin D may therefore be a potentially useful choice for raising VZV immunity in chronic dialysis patients. ? 2014 Macmillan Publishers Limited. All rights reserved.[SDGs]SDG31,25-dihydroxyvitamin D; hormone; immunoglobulin G; immunoglobulin M; mineral; virus antibody; vitamin D; adverse effects; aged; analogs and derivatives; blood; comorbidity; female; herpes zoster; human; immunocompromised patient; immunology; male; metabolism; middle aged; prospective study; renal replacement therapy; Varicella zoster virus; Aged; Antibodies, Viral; Comorbidity; Female; Herpes Zoster; Herpesvirus 3, Human; Hormones; Humans; Immunocompromised Host; Immunoglobulin G; Immunoglobulin M; Male; Middle Aged; Minerals; Prospective Studies; Renal Dialysis; Vitamin Djournal article10.1038/srep07371254876092-s2.0-84923290104