Lin, D.D.LinGong, T.T.GongQiu, S.S.QiuWu, Q.Q.WuTseng, C.-Y.C.-Y.TsengKong, K.V.K.V.KongChen, G.G.ChenChen, R.R.Chen2019-04-252019-04-252019https://www.scopus.com/inward/record.uri?eid=2-s2.0-85060914798&doi=10.1039%2fc8cc07461e&partnerID=40&md5=617792dd63c5c9c65a0425135f3f6174https://scholars.lib.ntu.edu.tw/handle/123456789/405951A dual signal amplification method based on surface-enhanced Raman scattering (SERS) is developed by photo-triggered release of SERS probes from mesoporous silica-coated Au nanorods (SiO2@Au) and the use of a specially-designed SERS substrate with an internal reference. Two metal carbonyl (metal-CO) labels (Os-SCO and Re-SCO) are proposed here as novel interference-free labels. Results demonstrate that tumor-related DNA can be quantitatively detected by this reliable and ultra-sensitive SERS platform. ? 2019 The Royal Society of Chemistry.[SDGs]SDG3carbonyl derivative; circulating tumor DNA; gold nanorod; mesoporous silica nanoparticle; coordination compound; DNA; gold; nanotube; osmium; rhenium; silicon dioxide; Article; branched DNA signal amplification assay; cancer diagnosis; controlled study; nasopharynx cancer; quantitative analysis; standard; surface enhanced Raman spectroscopy; chemistry; genetics; human; laser; metabolism; neoplasm; pathology; Raman spectrometry; Coordination Complexes; DNA, Neoplasm; Gold; Humans; Lasers; Nanotubes; Neoplasms; Osmium; Rhenium; Silicon Dioxide; Spectrum Analysis, Ramanjournal article10.1039/c8cc07461e2-s2.0-85060914798WOS:000457645500032