Cheng C.-C.Liang M.-C.Liao Z.-S.Huang J.-J.Lee D.-J.2019-05-142019-05-14201716165187https://scholars.lib.ntu.edu.tw/handle/123456789/408222Simple construction and manipulation of low-molecular-weight supramolecular nanogels, based on the introduction of multiple hydrogen bonding interactions, with the desired physical properties to achieve effective and safe delivery of drugs for cancer therapy remain highly challenging. Herein, a novel supramolecular oligomer cytosine (Cy)-polypropylene glycol containing self-complementary multiple hydrogen-bonded Cy moieties is developed, which undergoes spontaneous self-assembly to form nanosized particles in an aqueous environment. Phase transitions and scattering studies confirm that the supramolecular nanogels can be readily tailored to obtain the desired phase-transition temperature and temperature-induced release of the anticancer drug doxorubicin (DOX). The resulting nanogels exhibit an extremely high load carrying capacity (up to 24.8%) and drug-entrapment stability, making the loading processes highly efficient. Importantly, in vitro cytotoxicity assays indicate that DOX-loaded nanogels possess excellent biosafety for drug delivery applications under physiological conditions. When the environmental temperature is increased to 40 ¢XC, DOX-loaded nanogels trigger rapid DOX release and exert cytotoxic effects, significantly reducing the dose required compared to free DOX. Given its simplicity, low cost, high reliability, and efficiency, this newly developed temperature-responsive nanocarrier has highly promising potential for controlled release drug delivery systems. (Figure presented.). ? 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheimdrug deliverymultiple hydrogen bondsself-assemblysupramolecular nanogelsthermoresponsive polymers[SDGs]SDG3Cytotoxicity; Diseases; Drug delivery; Drug therapy; Hydrogels; Hydrogen bonds; Nanostructured materials; Oncology; Polypropylene oxides; Polypropylenes; Self assembly; Supramolecular chemistry; Controlled release drugs; Drug delivery applications; Environmental temperature; Multiple hydrogen bonding; Nanogels; Physiological condition; Temperature-responsive; Thermoresponsive polymer; Controlled drug delivery; cytosine; doxorubicin; drug carrier; glycol; polypropylene; polypropylene glycol; unclassified drug; antineoplastic antibiotic; doxorubicin; nanomaterial; aqueous solution; Article; biosafety; cancer therapy; controlled drug release; controlled study; cytotoxicity assay; drug delivery system; drug safety; drug stability; environmental temperature; gel; human; human cell; hydrogen bond; hydrophobicity; in vitro study; nanoencapsulation; nanomedicine; particle size; phase transition; physiological process; cell line; chemistry; proton nuclear magnetic resonance; transmission electron microscopy; Antibiotics, Antineoplastic; Cell Line; Doxorubicin; Drug Carriers; Humans; Hydrogen Bonding; Microscopy, Electron, Transmission; Nanostructures; Proton Magnetic Resonance Spectroscopyjournal article10.1002/mabi.2016003702-s2.0-85006512215https://www.scopus.com/inward/record.uri?eid=2-s2.0-85006512215&doi=10.1002%2fmabi.201600370&partnerID=40&md5=e8ac7f445429cac9d593d59278921d50