Identification of TMAO-producer phenotype and host-diet-gut dysbiosis by carnitine challenge test in human and germ-free mice

WEI-KAI WUCHIEH-CHANG CHENLiu, Po-YuPo-YuLiuPanyod, SuraphanSuraphanPanyodLiao, Ben-YangBen-YangLiaoChen, Pei-ChenPei-ChenChenHSIEN-LI KAOKuo, Han-ChunHan-ChunKuoCHING-HUA KUOChiu, Tina H TTina H TChiuChen, Rou-AnRou-AnChenChuang, Hsiao-LiHsiao-LiChuangHuang, Yen-TeYen-TeHuangZou, Hsin-BaiHsin-BaiZouCHENG-CHIH HSUChang, Ting-YanTing-YanChangLin, Chin-LonChin-LonLinHo, Chi-TangChi-TangHoHON-TSEN YULEE-YAN SHEENMING-SHIANG WU2023-01-162023-01-162019-08-010017-57491468-3288https://scholars.lib.ntu.edu.tw/handle/123456789/627288The gut microbiota-derived metabolite, trimethylamine N-oxide (TMAO) plays an important role in cardiovascular disease (CVD). The fasting plasma TMAO was shown as a prognostic indicator of CVD incident in patients and raised the interest of intervention targeting gut microbiota. Here we develop a clinically applicable method called oral carnitine challenge test (OCCT) for TMAO-related therapeutic drug efforts assessment and personalising dietary guidance.encardiovascular disease; gut microbiota; oral carnitine challenge test; trimethylamine n-oxideIdentification of TMAO-producer phenotype and host-diet-gut dysbiosis by carnitine challenge test in human and germ-free micejournal article10.1136/gutjnl-2018-317155303771912-s2.0-85056094720WOS:000482497600012