Lu, Hsuan-HsuanHsuan-HsuanLuSHU-YUNG LINWeng, Rueyhung RocRueyhung RocWengJuan, Yi-HsiuYi-HsiuJuanChen, Yen-WeiYen-WeiChenHSIN-HAN HOUHung, Zheng-CiZheng-CiHungOswita, Giovanni AudreyGiovanni AudreyOswitaHuang, Yi-JhenYi-JhenHuangGuu, Shih-YunShih-YunGuuKhoo, Kay-HooiKay-HooiKhooJIN-YUAN SHIHCHONG-JEN YUHSING-CHEN TSAI2021-07-062021-07-062020-0723523964https://scholars.lib.ntu.edu.tw/handle/123456789/569497Aberrant fucosylation plays a critical role in lung cancer progression. Nevertheless, the key fucosyltransferase with prognostic significance in lung cancer patients, the enzyme's intracellular targets, and complex molecular mechanisms underlying lung cancer metastasis remain incompletely understood.enCancer metastasis; Fucosyltransferase; Glycoproteomics; Lung cancer; Terminal fucosylation[SDGs]SDG3afatinib; fucosyltransferase; fucosyltransferase 4; galunisertib; mitogen activated protein kinase 3; nerve cell adhesion molecule; proteome; Rab protein; Smad2 protein; transcription factor Snail; transcriptome; unclassified drug; uvomorulin; vimentin; fucosyltransferase; FUT4 protein, human; glycoprotein; transcriptome; animal experiment; animal model; Article; cell invasion assay; cell migration assay; cell proliferation assay; cohort analysis; controlled study; down regulation; epithelial mesenchymal transition; fluorescence microscopy; fucosylation; gene expression; gene expression profiling; human; human cell; human tissue; immunofluorescence; immunoprecipitation; lung adenocarcinoma; lung nodule; major clinical study; male; matrix-assisted laser desorption-ionization mass spectrometry; metastasis; mouse; mRNA expression level; nonhuman; overall survival; phenotype; priority journal; protein expression; real time polymerase chain reaction; recurrence free survival; RNA interference; RNA sequencing; squamous cell lung carcinoma; tumor invasion; tumor xenograft; Western blotting; animal; carcinogenesis; cell adhesion; cell motion; gene expression regulation; genetics; lung adenocarcinoma; metastasis; pathology; signal transduction; tumor cell line; xenograft; Adenocarcinoma of Lung; Animals; Carcinogenesis; Cell Adhesion; Cell Line, Tumor; Cell Movement; Epithelial-Mesenchymal Transition; Fucosyltransferases; Gene Expression Regulation, Neoplastic; Glycoproteins; Heterografts; Humans; Mice; Neoplasm Metastasis; Signal Transduction; Transcriptomejournal article10.1016/j.ebiom.2020.102846326293862-s2.0-85087350002https://scholars.lib.ntu.edu.tw/handle/123456789/512567