骨科CHEN, JIANN-JONGJIANN-JONGCHENTSAI, SHIOW-CHWENSHIOW-CHWENTSAILU, CHIEN-CHENCHIEN-CHENLULEE, KUN-YEEKUN-YEELEECHIEN, CHAU-HENGCHAU-HENGCHIENTSAI, CHING-LINCHING-LINTSAIWANG, PAULUS, SPAULUS, SWANGCHIEN, EILEEN, JEAEILEEN, JEACHIEN2009-01-192018-07-132009-01-192018-07-131994http://ntur.lib.ntu.edu.tw//handle/246246/99077　　The effect of human calcitonin (hCT) on the secretion of luteinizing hormone (LH) was examined in castrated rats. Male rats were orchiectomized(Orch) 2 weeks before they were treated with a single bolus injection of gonadotropin- releasing hormone (GnRH, 1 mk/kg of body dweight), hCT (3.4 ng/kg), or the combination of GnRH and hCT through a right jugular vein catheter. Blood sampoles (0.5 ml each time) were collected immeiately before (0-min) and then at 15, 30, 60,120 and 180 min after hormone infection. Plasma LH concentration was measured with a radioimmunoassay technique. Plasma calcium concentration was determined in an automatic analyzer. hCT singificantly diminished both the basal and GnRH-stimulated levels of pllasma LH without any relation to the reduced plasma levels of calcium. These results clearly demonstrated a plasma calcium- unrelated inhibitory effect of hCT on LH secretion. #2279#en-US