Lu, Yu-ChengYu-ChengLuCHAO-YUAN HUANGCHIA-HSIEN CHENGKUO-HOW HUANGYU-CHUAN LUPO-MING CHOWYI-KAI CHANGYEONG-SHIAU PUCHUNG-HSIN CHENSHAO-LUN LUKENG-HSUEH LANFU-SHAN JAWChen, Pei-LingPei-LingChenJIAN-HUA HONG2022-12-212022-12-212022-07-212045-2322https://scholars.lib.ntu.edu.tw/handle/123456789/626712To compare clinical outcomes between the use of robotic-assisted laparoscopic radical prostatectomy (RP) and radiotherapy (RT) with long-term androgen deprivation therapy (ADT) in locally advanced prostate cancer (PC), 315 patients with locally advanced PC (clinical T-stage 3/4) were considered for analysis retrospectively. Propensity score-matching at a 1:1 ratio was performed. The median follow-up period was 59.2 months (IQR 39.8-87.4). There were 117 (37.1%) patients in the RP group and 198 (62.9%) patients in the RT group. RT patients were older and had higher PSA at diagnosis, higher Gleason score grade group and more advanced T-stage (all p < 0.001). After propensity score-matching, there were 68 patients in each group. Among locally advanced PC patients, treatment with RP had a higher risk of biochemical recurrence compared to the RT group. In multivariate Cox regression analysis, treatment with RT plus ADT significantly decreased the risk of biochemical failure (HR 0.162, p < 0.001), but there was no significant difference in local recurrence, distant metastasis and overall survival (p = 0.470, p = 0.268 and p = 0.509, respectively). This information supported a clinical benefit in BCR control for patients undergoing RT plus long-term ADT compared to RP.enUROLOGICAL RESEARCH; SURVIVAL; TRIAL[SDGs]SDG3journal article10.1038/s41598-022-16700-7358642932-s2.0-85134592555WOS:000828780000001https://scholars.lib.ntu.edu.tw/handle/123456789/620621