CHIH-MIN LIULiu Y.-L.Fann C.S.-J.Yang W.-C.Wu J.-Y.Hung S.-I.WEI J. CHENChueh C.-M.Liu W.-M.CHEN-CHUNG LIUFaraone S.V.TZUNG-JENG HWANGMING-HSIEN HSIEHTsuang M.T.HAI-GWO HWU2020-03-172020-03-172007-07https://scholars.lib.ntu.edu.tw/handle/123456789/476438Several linkage studies have shown significant linkage of schizophrenia to chromosome 6p region, which includes the positional candidate genes, Dystrobrevin-binding protein 1 (DTNBP1). The aim was to examine the association evidence of the candidate gene in 693 Taiwanese families with at least two affected siblings of schizophrenia. We genotyped nine SNPs of this gene with average intermarker distance of 17?kb. Intermarker linkage disequilibrium was calculated with GOLD. Single locus and haplotype association analyses were performed with TRANSMIT program. We found no significant association between schizophrenia and DTNBP1 either through single locus or haplotype analyses. We failed to replicate the association evidence between DTNBP1 and schizophrenia and this gene may not play a major role in the etiology of schizophrenia in this Taiwanese family sample. ? 2007 Elsevier B.V. All rights reserved.[SDGs]SDG3dystrobrevin binding protein 1; protein; unclassified drug; adult; article; Chinese; disease association; female; gene linkage disequilibrium; gene locus; genotype; haplotype; human; major clinical study; male; priority journal; schizophrenia; sibling; Taiwan; Adult; Asian Continental Ancestry Group; Carrier Proteins; Chromosomes, Human, Pair 6; Female; Genetic Markers; Genetic Predisposition to Disease; Genotype; Haplotypes; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Schizophrenia; Siblings; Taiwanjournal article10.1016/j.schres.2007.02.003174078052-s2.0-34249302041