2016-01-012024-05-17https://scholars.lib.ntu.edu.tw/handle/123456789/680357摘要：高強度聚焦超音波是一種快速發展中的醫療技術，它是應用於人體組織上的非侵入式腫瘤切除治療。肝癌不僅在亞洲是排名第二的死亡原因，在全球排名更高居榜首。利用聚焦超音波治療肝腫瘤會引起因血管發熱所產生的問題，自然冷卻雖然可以減少細胞的壞死，卻會使得腫瘤再次的生長。為了避免血管的壞死與腫瘤細胞的重生，因此必須對影響腫瘤切除的因素有一基本的認知，使得治療過程有最佳化的規劃。為了進一步了解血管與超音波聚焦位置對於高強度聚焦超音波療程中的溫度分佈所造成的影響，將透過一個三維的聲、熱、流耦合的數學模型來計算肝癌分佈區域的溫度場。此一三維的聲、熱、流耦合模型包括非線性Westervelt聲波方程、生物熱傳導方程以及非線性Navier-Stokes方程。因聲波傳遞所造成的影響也將一併考慮。同時，將建立一個療程規劃平台，並搭配核磁共振成像技術，研究在真實肝臟情況下的非侵入式高強度聚焦超音波的燒灼腫瘤的技術。 在生理運作的過程中，特化的膜蛋白所組成的離子通道扮演了重要的角色。近年來的研究指出，不正常的離子通道運動行為與癌細胞的生長增值和遷移有關。藉由離子通道來傳遞離子在癌細胞的增長過程中扮演了重要的角色，其離子傳輸行為可以透過Monte Carlo法與分子動力學來模擬。然而，這些方法需要耗費大量的計算資源，而且其計算效率受到限制。在本研究計畫中，我們將建立新的數學模型，以對流擴散方程更有效率地模擬離子通道中的離子傳輸行為。 <br> Abstract: High intensity focused ultrasound (HIFU) is a rapidly developing medical technology for a non-invasive tumor ablation therapy in various organs of the body. Liver cancer is the second leading cause of death in Asia and is now known as one of the most leading causes of death in the world. Focused ultrasound treatment of liver tumor is problematic, because large blood vessels act as a heat sink. Convective cooling can reduce necrosed volume and liver can regenerate. To avoid the damage of large blood vessels and regeneration of tumor, basic understanding of the factors that affect the tumor ablation is necessary for planning and optimization of the treatment. The influence of blood vessels and focused location on the temperature distribution during HIFU therapy is investigated. A three-dimensional acoustic-thermal-fluid coupling model enables to compute the temperature field in the hepatic cancerous region. The model is based on the nonlinear Westervelt and bioheat equations as well as the nonlinear Navier-Stokes equations for the blood flow in the liver parenchyma. The effect of acoustic streaming is also taken into account. A surgical planning platform for the non-invasive HIFU tumor ablating therapy in real liver geometry on the basis of the MRI image is under current construction. As targets for cancer therapy, ion channels are specialized membrane proteins that play important roles in various physiological processes. Recent studies have shown that abnormal expression and/or activity of a number of ion channels are involved in the growth/proliferation, migration and/or invasion of cancer cells. Ion transport across ion channels may play a key role in the development of cancer and can be simulated by Monte Carlo and molecular dynamics methods conventionally. However, the cost of these methods is expensive and the efficiency is limited. In this project, we want to find a more effective way to simulate ion transport across ion channels by deriving a new macroscopic model with the form of convection-diffusion equation.高強度聚焦超音波非侵入式腫瘤切除治療肝腫瘤聲熱流耦合數學模型離子通道High intensity focused ultrasoundnon-invasive tumor ablation therapyliver tumoracoustic-thermal-fluid coupling modelion channel