Inhibition of Viral Replication Reduces Transcriptionally Active Distinct Hepatitis B Virus Integrations With Implications on Host Gene Dysregulation

Hsu, Yao-ChunYao-ChunHsuSuri, VithikaVithikaSuriNguyen, Mindie HMindie HNguyenHuang, Yen-TsungYen-TsungHuangChen, Chi-YiChi-YiChenChang, I-WeiI-WeiChangTseng, Cheng-HaoCheng-HaoTsengWu, Chun-YingChun-YingWuJAW-TOWN LINPan, David ZDavid ZPanGaggar, AnujAnujGaggarPodlaha, OndrejOndrejPodlaha2023-09-112023-09-112022-0400165085https://www.scopus.com/record/display.uri?eid=2-s2.0-85125910391&doi=10.1053%2fj.gastro.2021.12.286&origin=inward&txGid=1424ac0195f2d6e7d40c0aafae79b415https://scholars.lib.ntu.edu.tw/handle/123456789/635317Hepatocellular carcinogenesis of hepatitis B virus (HBV) infection may arise from integration of viral DNA into the host genome. We aimed to gauge the effect of viral inhibition on transcriptionally active HBV-host integration events and explore the correlation of viral integrations with host gene dysregulation.enAntiviral Treatment; Chronic Hepatitis B; Hepatocellular Carcinogenesis; Transcriptome Analysis; Viral IntegrationInhibition of Viral Replication Reduces Transcriptionally Active Distinct Hepatitis B Virus Integrations With Implications on Host Gene Dysregulationjournal article10.1053/j.gastro.2021.12.286349955362-s2.0-85125910391https://api.elsevier.com/content/abstract/scopus_id/85125910391