黃耀輝2006-07-252018-06-292006-07-252018-06-292000-07-31http://ntur.lib.ntu.edu.tw//handle/246246/4944本計劃研究目的為分析鉛蓄電池廠鉛塵之 物化特性，並評估其相對生物攝取率。動 物實驗部分以九十隻雄性Sprague-Dawley 大鼠進行餵食含不同鉛粉塵飼料之觀察， 餵食劑量分別設定5 及10 mg/KgBW/day ， 觀察期為2 至6 週。研究結果顯示，陰極 鉛粉和陽極極板整理粉塵的組成成分為鉛 與二氧化鉛，其他類別的粉塵則僅含元素 態鉛。鉛粉原料的粒徑全部小於80um ，眾 數大小為11~12 um 。66%~75%的極板整理 粉塵之粒徑小於250 um ，而僅27%的極板 裁切粉塵小250um 。陰極鉛粉原料、陰極 極板整理粉塵及極板裁切粉塵的重量組成 中，幾乎全是鉛及其化合物。另外，一般 而言實驗動物的血鉛值會隨攝食之鉛粉塵 粒徑減小而增加較快。並且，高劑量組的 實驗顯示，在第二週即可達到體內穩定血 中鉛值；而低劑量組則要在第四週才可達 到。在相同暴露劑量的狀況下，各種不同 鉛粉塵來源的生物攝取率並不同，最低的 是由106um~250um 粒徑範圍的陰極極板 粉塵所觀察到的30.9%生物攝取率，最高 的是由眾數粒徑為12um 的陰極鉛粉原料 所觀察到的245.1%。本計劃研究結果可提 供進一步鉛蓄電池廠鉛暴露風險評估的重 要參數，特別是有關於不經意狀況下食入 前粉塵或由上呼吸到排除轉移到腸胃道到吸收的鉛塵暴露。This study was conducted to characterize the physicochemical properties of the lead powder/dust from a lead battery plant, and estimate their relative bioavailability. Ninety male Sprague-Dawley rats were fed with lead-dosed mixtures at the target doses of 5 and 10 mg/Kg BW/day, respectively, during the specified study periods. Results shows that lead powder for anode and the lead dust from the cathode plate manipulating process consisted of both lead element and lead oxide while the other types of lead powder or dust were found composed of lead element only. Also, it is shown that the lead powder was the smallest in particle size with a mode of 11~12 um, while 66%~75% of lead dust from plate manipulating process and 27% of that from plate cutting process were composed of particle size less 250 um. Lead powder for anode plate, lead dust from the anode electrode plate manipulating process, and from the plate cutting process were mostly composed of lead and/or its compounds, in terms of weight percentage. Generally speaking, the blood lead levels increased inversely with the particle size of the lead powder and/or dust, and reached the plateau level around the 4 th week for the low dose group and about the 2 nd week for the high dose group. At the same lead exposure dose, the bioavailability of lead uptake vary from 30.9% for the lead dust from anode plate manipulating process with size range of 106um~250um to 245.1% of lead powder for anode plate with size mode of 12 um, depending on the lead source and the time period of blood collection. The observations in the present study provide important parameters for the improved risk assessment of exposure to lead dust in the lead battery plant, especially for inadvertent ingestion and/or ingestion of coarse particles transferred from the naso-pharyngeal area to the gastro-intestinal tract.application/pdf73757 bytesapplication/pdfzh-TW國立臺灣大學公共衛生學院職業醫學與工業衛生研究所鉛生物攝取率動物研究鉛蓄電池廠粉塵LeadBioavailabilityAnimal StudyLead Battery PlantDustreporthttp://ntur.lib.ntu.edu.tw/bitstream/246246/4944/1/892320B002037.pdf