臺大醫院;臺大醫院-牙科部;臺大醫學院;臺大醫學院-口腔生物科學研究所;臺大醫學院-牙醫學系;臺大醫學院-臨床牙醫學研究所;CHUN-PIN CHIANGHuang, Wan-TingWan-TingHuangLee, Jeng-WoeiJeng-WoeiLeeHsu, Yih-ChihYih-ChihHsu2018-09-102018-09-102012http://www.scopus.com/inward/record.url?eid=2-s2.0-84858072859&partnerID=MN8TOARShttp://scholars.lib.ntu.edu.tw/handle/123456789/368360Background Previous studies found that topical photodynamic therapy (PDT) is very effective for human oral precancerous lesions. Methods This study evaluated whether topical photosan-mediated PDT (topical photosan-PDT), using a 640-nm light-emitting diode (LED) light, is an effective treatment modality for hamster buccal pouch precancerous lesions. Fourteen 7,12-dimethylbenz(a) anthracene (DMBA)-induced hamster buccal pouch precancerous lesions were treated with topical photosan-PDT using the 640-nm LED light twice a week. Results All 14 of the precancerous lesions showed a complete histologically confirmed response to the lesions after an average of 3.79 (range, 3-5) PDT treatments. Normal and precancerous pouch mucosae in the other 4 hamsters received 17 or 19 treatments of topical photosan-PDT showed no cumulative side effects. No recurrence of the lesions was found in these 18 PDT-treated hamsters after a follow-up period of 50 weeks. Conclusion Our findings indicate that topical photosan-PDT is a very effective treatment modality for DMBA-induced hamster buccal pouch precancerous lesions. Copyright ? 2011 Wiley Periodicals, Inc.99 bytestext/htmlDMBA; hamster buccal pouch precancer; oral precancerous lesions; photosan; topical photodynamic therapy[SDGs]SDG37,12 dimethylbenz[a]anthracene; hematoporphyrin derivative; animal experiment; animal model; animal tissue; article; cheek pouch precancer; controlled study; follow up; histopathology; light emitting diode; male; nonhuman; photodynamic therapy; precancer; priority journal; treatment outcome; treatment response; 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Biopsy, Needle; Cheek; Cricetinae; Disease Models, Animal; Hematoporphyrins; Immunohistochemistry; Male; Mouth Neoplasms; Photochemotherapy; Photosensitizing Agents; Precancerous Conditions; Random Allocation; Reference Values; Spectrometry, Fluorescence; Treatment Outcomejournal article10.1002/hed.21761