JUI WANGSZU-YING LEECHIA-TER CHAOJENQ-WEN HUANGKUO-LIONG CHIEN2022-09-152022-09-152022-06-1400219150https://scholars.lib.ntu.edu.tw/handle/123456789/620424https://www.scopus.com/inward/record.uri?eid=2-s2.0-85133714925&doi=10.1016%2fj.atherosclerosis.2022.06.1010&partnerID=40&md5=a5178b4b9be967b16dff541deb240431Background and aims: Frailty denotes the increased vulnerability to stressors/insults associated with aging or diseases, and has high incidence in patients with diabetes mellitus (DM). We hypothesized that chronic kidney disease (CKD) and non-kidney morbidities in patients with newly diagnosed DM might modulate their risk of developing incident frailty. Methods: From the Longitudinal Cohort of Diabetes Patients, we identified 322,109 patients with newly diagnosed DM, and classified them into those without CKD, with CKD before and after DM. We used Kaplan-Meier analyses and Cox proportional hazard regression to analyze associations between CKD or non-kidney morbidities and the risk of incident frailty. We further analyzed the year-to-year trend of frailty risk brought by CKD or non-kidney morbidities. Results: Patients with DM but without CKD (n = 249,752; 77.5%), with CKD prior to (n = 23,829; 7.4%), and after DM (n = 48,528; 15.1%) were enrolled. Those with CKD, regardless of onset timing, had a significantly higher risk of developing frailty than those without (for onset prior to DM, hazard ratio (HR) 1.235, 95% confidence interval (CI) 1.11–1.38; for onset after DM, HR 1.386, 95% CI 1.21–1.59). The risk was more prominent early after the diagnosis of DM was made. Patients with chronic obstructive pulmonary disease, liver, and cardiovascular morbidities all had a significantly higher risk of frailty than those without, with cerebrovascular accident carrying the most prominent risk elevation (HR 4.059, 95% CI 3.73–4.42). Conclusions: CKD regardless of onset timing relative to DM predicted a higher risk of incident frailty, while non-kidney morbidities including cardiovascular morbidities, similarly increased frailty risk among incident diabetic patients. © 2022 Elsevier B.V.enChronic kidney disease; Diabetes mellitus; Diabetic kidney disease; Frail phenotype; Frailty; Heart failure[SDGs]SDG2[SDGs]SDG3[SDGs]SDG5journal article10.1016/j.atherosclerosis.2022.06.1010357985722-s2.0-85133714925https://api.elsevier.com/content/abstract/scopus_id/85133714925