Eradication of intracellular Francisella tularensis in THP-1 human macrophages with a novel autophagy inducing agent

HAO-CHIEH CHIUSoni, S.S.SoniKulp, S.K.S.K.KulpCurry, H.H.CurryWang, D.D.WangGunn, J.S.J.S.GunnSchlesinger, L.S.L.S.SchlesingerChen, C.S.C.S.Chen2021-05-282021-05-282009-121423-0127https://scholars.lib.ntu.edu.tw/handle/123456789/563422Autophagy has been shown recently to play an important role in the intracellular survival of several pathogenic bacteria. In this study, we investigated the effect of a novel small-molecule autophagy-inducing agent, AR-12, on the survival of Francisella tularensis, the causative bacterium of tularemia in humans and a potential bioterrorism agent, in macrophages.en[SDGs]SDG16Eradication of intracellular Francisella tularensis in THP-1 human macrophages with a novel autophagy inducing agentjournal article10.1186/1423-0127-16-110200031802-s2.0-76249102863http://www.scopus.com/inward/record.url?eid=2-s2.0-76249102863&partnerID=MN8TOARS27670273