Kuo C.-Y.Yen M.-F.Chen L.-S.Fann C.-Y.Chiu Y.-H.Chen, Tony Hsiu HsiTony Hsiu HsiChenSHIN-LIANG PAN2020-04-072020-04-0720131932-6203https://www.scopus.com/inward/record.uri?eid=2-s2.0-84872874634&doi=10.1371%2fjournal.pone.0055253&partnerID=40&md5=87923920e3997aa38a8895eedd74c196https://scholars.lib.ntu.edu.tw/handle/123456789/482884Objective: Previous studies on the association between migraine and the risk of developing hemorrhagic stroke (HS) have generated inconsistent results. The aim of the present population-based, age- and sex- matched follow-up study was to investigate whether migraine is associated with an increased risk of HS. Method: A total of 20925 persons with at least two ambulatory visits in 2001 with the principal diagnosis of migraine were enrolled in the migraine group. The non-migraine group consisted of 104625, age- and sex- matched, randomly sampled subjects without migraine. The two-year HS-free survival rates for these 2 groups were estimated using the Kaplan-Meier method. Cox proportional hazards regression was used to estimate the effect of migraine on the occurrence of HS. Results: During the 2 year follow-up, 113 subjects in the migraine group (0.54%) and 255 in the non-migraine group (0.24%) developed HS. The crude hazard ratio (HR) for developing HS in the migraine group was 2.22 compared to the non-migraine group (95% confidence interval [CI]: 1.78-2.77, p<0.0001) and the adjusted HR was 2.13 (95% CI: 1.71-2.67, p<0.0001) after controlling for demographic characteristics and comorbid medical disorders. Conclusions: This population-based age- and sex- matched cohort study shows that migraine was linked to an increased risk of HS. ? 2013 Kuo et al.[SDGs]SDG3adult; article; brain hemorrhage; cohort analysis; controlled study; disease association; disease free survival; female; high risk patient; human; hyperlipidemia; hypertension; ischemic heart disease; major clinical study; male; migraine; prevalence; rheumatic heart disease; risk assessment; survival rate; Adult; Cohort Studies; Female; Humans; Intracranial Hemorrhages; Male; Middle Aged; Migraine Disorders; Population Surveillance; Proportional Hazards Models; Risk; Strokejournal article10.1371/journal.pone.0055253233728432-s2.0-84872874634