SHU-HUA YANGCHEN-TU WUWang C.-J.Kuo M.-S.RONG-SEN YANG2021-05-312021-05-3120000929-6646https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033822986&partnerID=40&md5=25a9d56b656c73c95286f702bf68ea24https://scholars.lib.ntu.edu.tw/handle/123456789/563828Intracortical osteosarcoma is the rarest anatomic variation of osteosarcoma. There have been only 12 cases reported in the English-language literature. We present a case of osteosarcoma in an 18-year-old Taiwanese man that originated within the cortex of the tibial diaphysis. The initial radiograph revealed a lyric mass confined to the cortex, mimicking a benign bone lesion. Histopathologic examination of the biopsy specimen showed an osteoblastic osteosarcoma mingled with some fibroblastic foci. He underwent en bloc resection, and a metallic prosthetic intercalary stem was used to replace the larger bone defect. Adjuvant chemotherapy was administered before and after the operation. He was free of disease during 40 months of follow-up. A review of all reported cases of intracortical osteosarcoma revealed that the initial method of treatment plays an important role in local recurrence and distant metastasis. Local excision and curettage leads to the worst results. The outcomes of more recently reported cases have improved because of early awareness of the possibility of malignancy and advances in chemotherapy. However, whether patients with intracortical osteosarcoma have a different prognosis from those with conventional osteosarcoma cannot be determined, because of the small number of intracortical osteosarcoma cases available for analysis.en[SDGs]SDG3adult; anatomical variation; article; case report; follow up; histopathology; human; human cell; human tissue; male; osteosarcoma; surgical anatomy; surgical technique; treatment outcome; Adolescent; Bone Neoplasms; Humans; Male; Osteosarcomajournal article110007372-s2.0-0033822986000089263100009https://publons.com/wos-op/publon/32960278/