Chen, Yu-JenYu-JenChenHuang, Ying-ZuYing-ZuHuangChen, Chung-YaoChung-YaoChenChen, Chia-LingChia-LingChenChen, Hsieh-ChingHsieh-ChingChenWu, Ching-YiChing-YiWuKEH-CHUNG LINChang, Tzu-LingTzu-LingChang2020-03-242020-03-242019-04-251471-2377https://scholars.lib.ntu.edu.tw/handle/123456789/478455Background Intermittent theta burst stimulation (iTBS) is a form of repetitive transcranial stimulation that has been used to enhance upper limb (UL) motor recovery. However, only limited studies have examined its efficacy in patients with chronic stroke and therefore it remains controversial. Methods This was a randomized controlled trial that enrolled patients from a rehabilitation department. Twenty-two patients with first-ever chronic and unilateral cerebral stroke, aged 30–70 years, were randomly assigned to the iTBS or control group. All patients received 1 session per day for 10 days of either iTBS or sham stimulation over the ipsilesional primary motor cortex in addition to conventional neurorehabilitation. Outcome measures were assessed before and immediately after the intervention period: Modified Ashworth Scale (MAS), Fugl-Meyer Assessment Upper Extremity (FMA-UE), Action Research Arm Test (ARAT), Box and Block test (BBT), and Motor Activity Log (MAL). Analysis of covariance was adopted to compare the treatment effects between groups. Results The iTBS group had greater improvement in the MAS and FMA than the control group (η2 = 0.151–0.233; p < 0.05), as well as in the ARAT and BBT (η2 = 0.161–0.460; p < 0.05) with large effect size. Both groups showed an improvement in the BBT, and there were no significant between-group differences in MAL changes. Conclusions The iTBS induced greater gains in spasticity decrease and UL function improvement, especially in fine motor function, than sham TBS. This is a promising finding because patients with chronic stroke have a relatively low potential for fine motor function recovery. Overall, iTBS may be a beneficial adjunct therapy to neurorehabilitation for enhancing UL function. Further larger-scale study is warranted to confirm the findings and its long-term effect. Trial registration This trial was registered under ClinicalTrials.gov ID No. NCT01947413 on September 20, 2013.enMotor function; Rehabilitation; Stroke; Theta burst stimulation (TBS); Transcranial magnetic stimulation (TMS)[SDGs]SDG3Action Research Arm Test; adult; aged; Article; Box and Block test; brain function; cerebrovascular accident; chronic disease; clinical article; clinical assessment; comparative study; controlled study; daily life activity; female; Fugl Meyer Assessment Upper Extremity; human; intermittent theta burst stimulation; intervention study; long term care; male; Modified Ashworth Scale; Motor Activity Log; motor dysfunction assessment; motor performance; neurorehabilitation; outcome assessment; pilot study; primary motor cortex; randomized controlled trial; repetitive transcranial magnetic stimulation; therapy effect; upper limb; chronic disease; convalescence; middle aged; pathophysiology; physiology; procedures; spasticity; stroke rehabilitation; transcranial magnetic stimulation; treatment outcome; upper limb; Adult; Aged; Chronic Disease; Female; Humans; Male; Middle Aged; Muscle Spasticity; Pilot Projects; Recovery of Function; Stroke Rehabilitation; Transcranial Magnetic Stimulation; Treatment Outcome; Upper Extremityjournal article10.1186/s12883-019-1302-x310232582-s2.0-85065322612WOS:000465901000001https://api.elsevier.com/content/abstract/scopus_id/85065322612