環境暨職業醫學科LIN, CHENG-YUCHENG-YULINSHIH, TUNG-SHENGTUNG-SHENGSHIHGUO, YUE-LIANGYUE-LIANGGUOWU, JIUNN-LIANGJIUNN-LIANGWUSUN, YIH-MINYIH-MINSUNTSAI, PERNG-JYPERNG-JYTSAI���|�}2012-07-122018-07-112012-07-122018-07-112011http://ntur.lib.ntu.edu.tw//handle/246246/241881In this study we assessed the interaction between glutathione S- transferase (GST) genetic polymorphisms and noise exposures, with regard to their effect on the hearing threshold levels for high frequencies ( HTLHF). Research participants comprised 347 male workers, and each participant's cumulative noise exposure was determined using a job- exposure matrix. Approximately 64.6% of the participants' exposure in L(eq -8 h) was above 90 dBA. The mean HTLHF was 32.1 dB. A significant dose- response relationship was found between noise exposure and HTLHF. We further converted the estimated total noise exposure level over each participant's job history to a noise exposure level that corresponded to a 40-year exposure (L(eq-40y)). After we had adjusted the results for age, we found that workers carrying GSTM1 null, GSTT1 null, and GSTP1 Ile(105)/ Ile(105) genotypes were susceptible to the HTLHF when their L(eq-40y) were above 90 dBA. Therefore, GST genetic polymorphisms might affect HTLHF only when workers are exposed to high noise levels.en-US