Targeting ER protein TXNDC5 in hepatic stellate cell mitigates liver fibrosis by repressing non-canonical TGFβ signalling

Hung, Chen-TingChen-TingHungTUNG-HUNG SUChen, Yen-TingYen-TingChenWu, Yueh-FengYueh-FengWuYOU-TZUNG CHENSUNG-JAN LINSHUEI-LIONG LINKAI-CHIEN YANG2022-09-292022-09-292022-09-010017-5749https://scholars.lib.ntu.edu.tw/handle/123456789/623254Liver fibrosis (LF) occurs following chronic liver injuries. Currently, there is no effective therapy for LF. Recently, we identified thioredoxin domain containing 5 (TXNDC5), an ER protein disulfide isomerase (PDI), as a critical mediator of cardiac and lung fibrosis. We aimed to determine if TXNDC5 also contributes to LF and its potential as a therapeutic target for LF.enapoptosis; fibrogenesis; gene targeting; hepatic stellate cell; liver cirrhosis[SDGs]SDG3Targeting ER protein TXNDC5 in hepatic stellate cell mitigates liver fibrosis by repressing non-canonical TGFβ signallingjournal article10.1136/gutjnl-2021-325065349339152-s2.0-85136339657WOS:000733416300001https://scholars.lib.ntu.edu.tw/handle/123456789/622533