WEI-WEN WUSHAO-YU TSAILiang S.-Y.Liu C.-Y.SHIANN-TANG JOUBerry D.L.2021-01-052021-01-0520151043-4542https://www.scopus.com/inward/record.uri?eid=2-s2.0-84938844076&doi=10.1177%2f1043454214563758&partnerID=40&md5=5e3181cdb8e9182d0142df7cc905a5ddhttps://scholars.lib.ntu.edu.tw/handle/123456789/537727Understanding how cancer symptom distress and resilience contribute to quality of life (QoL) in adolescent cancer and may potentially help these patients achieve better health-related outcomes. The objective of this study was to describe cancer symptom distress, QoL, and resilience in adolescents with cancer and to determine whether resilience is a mediating variable. Forty adolescent cancer patients were recruited, and data were collected via a demographic questionnaire, the Cancer Symptom Distress Scale, the Resilience Scale, and the Minneapolis-Manchester Quality of Life Scale. Pearson’s correlation, multiple regressions, and the Sobel test were conducted. Both resilience and cancer symptom distress were regressed against QoL, accounting for 62.1% of observed variation in QoL scores. The bootstrap result estimated the true indirect effect between ?.0189 and ?.0024, with a 95% confidence interval. Resilience mediates the relationship between cancer symptom distress and QoL. Clinical use of a resilience measure, for example to use in developing and evaluating interventions focused on enhancing resilience, may be practical for nurses. ? 2015, ? 2015 by Association of Pediatric Hematology/Oncology Nurses.adolescent; cancer symptom; mediating effect; quality of life; resilience[SDGs]SDG3adolescent; child health care; coping behavior; female; human; male; mental stress; neoplasm; nursing; oncology nursing; pediatric nursing; psychology; quality of life; questionnaire; young adult; Adolescent; Adolescent Health Services; Female; Humans; Male; Neoplasms; Oncology Nursing; Pediatric Nursing; Quality of Life; Resilience, Psychological; Stress, Psychological; Surveys and Questionnaires; Young Adultjournal article10.1177/1043454214563758256128352-s2.0-84938844076