Liu T.-Y.Chen, Chien-YuanChien-YuanChenHWEI-FANG TIENCHUNG-WU LIN2020-03-032020-03-0320090309-0167https://www.scopus.com/inward/record.uri?eid=2-s2.0-58649097509&doi=10.1111%2fj.1365-2559.2008.03199.x&partnerID=40&md5=e3cbf97b9a581fee636fb965e0f705d0https://scholars.lib.ntu.edu.tw/handle/123456789/468894Aims: Loss of CD7 is characteristic of adult T-cell lymphoma/leukaemia (ATLL). Galectin-3 (Gal-3) is strongly induced in cultured human T lymphotropic virus-1-infected T lymphocytes, and may cause apoptosis through interaction with CD7. The aim was to investigate the clinical relevance of the Gal-3-CD7 pathway in ATLL. Methods and results: Immunohistochemistry for Gal-3 and CD7 was performed on 22 cases of ATLL in the leukaemic phase. We found that the lymphoma cells were not necessarily Gal-3+, but Gal-3+ stromal cells could always be found. Independent of the status of Gal-3, there was an association of loss of CD7 with a worse prognosis. Conclusions: These data suggest that, by down-regulating CD7, ATLL cells could have escaped Gal-3-induced apoptosis to run a more aggressive clinical course. ? 2008 Blackwell Publishing Limited.[SDGs]SDG3CD7 antigen; galectin 3; acute disease; adult; aged; article; chromosome 9p; chronic disease; controlled study; ethnic difference; female; human; human tissue; immunohistochemistry; major clinical study; male; priority journal; prognosis; protein expression; stroma cell; T cell leukemia; Adult; Aged; Antigens, CD7; Apoptosis; Cells, Cultured; Chromosome Aberrations; Down-Regulation; Female; Galectin 3; Humans; Immunohistochemistry; Leukemia-Lymphoma, Adult T-Cell; Male; Middle Aged; Prognosis; Human T-lymphotropic virus 1journal article10.1111/j.1365-2559.2008.03199.x192079462-s2.0-58649097509