Liao H.-F.Lin M.-H.Hsiao C.-H.YI-HUA LIAO2019-12-042019-12-0420071027-8117https://www.scopus.com/inward/record.uri?eid=2-s2.0-34250696376&partnerID=40&md5=a39d9aac46a5c5f105c038332dc5784bhttps://scholars.lib.ntu.edu.tw/handle/123456789/434828We report a case with multiple acral squamous cell carcinomas (SCCs) associated with human papillomavirus (HPV) type 49 and 16 infection in separate lesions. HPV 49 belongs to the epidermodysplasia verruciformis (EV)-HPV group. It has only been detected in flat warts and one SCC in a renal transplant patient in the past literature. Our report showed the first case of SCC associated with HPV 49 in an immunocompetent patient. In addition, the high risk mucosal HPV 16 DNA was also detected in a palmar wart as well as the digital SCC of this patient. This finding indicates that HPV 16 might be a risk factor in the continuum of malignant progression from wart to cutaneous SCC. The local recurrence rate of the HPV 16-associated digital SCC was reported to be higher than HPV-negative digital SCC, and more aggressive treatment and long-term follow-up were indicated.Cutaneous squamous cell carcinoma; HPV 16; HPV 49; Human papillomavirus[SDGs]SDG3liquid nitrogen; virus DNA; aged; anamnesis; article; cancer growth; cancer radiotherapy; case report; disease association; DNA sequence; epidermodysplasia verruciformis; erythema; follow up; gene amplification; human; Human papillomavirus type 16; Human papillomavirus type 49; human tissue; hyperkeratosis; immunocompetence; kidney transplantation; long term care; male; photodynamic therapy; physical examination; polymerase chain reaction; recurrent disease; risk factor; skin biopsy; split thickness skin graft; squamous cell carcinoma; treatment refusal; verruca vulgaris; virus gene; virus typing; Wart virusjournal article2-s2.0-34250696376