Tang Y.Liu X.Liu X.Li Y.Wu K.Hou X.2019-07-172019-07-17201716742052https://scholars.lib.ntu.edu.tw/handle/123456789/414208Light is a crucial environmental signal that promotes photomorphogenesis, the developmental process with a series of light-dependent alterations for plants to adapt various external challenges. Chromatin modification has been proposed to be involved in such light-mediated growth, but the underlying mechanism is still elusive. In this study, we identified four Arabidopsis thaliana Nuclear Factor-YC homologs, NF-YC1, NF-YC3, NF-YC4, and NF-YC9 (NF-YCs), which function redundantly as repressors of light-controlled hypocotyl elongation via histone deacetylation. Obvious etiolation phenotypes are observed in NF-YCs loss-of-function mutant seedlings grown under light conditions, including significant elongated hypocotyls and fewer opened cotyledons. We found that?NF-YCs interact with histone deacetylase HDA15 in the light, co-target the promoters of a set of hypocotyl elongation-related genes, and modulate the levels of histone H4 acetylation on the?associated chromatins, thus repressing gene expression. In contrast, NF-YC-HDA15 complex is dismissed from the target genes in the dark, resulting in increased level of H4 acetylation and?consequent etiolated growth. Further analyses revealed that transcriptional repression activity of NF-YCs on the light-controlled hypocotyl elongation partially depends on the deacetylation activity of HDA15, and loss of HDA15 function could rescue?the short-hypocotyl phenotype of NF-YCs overexpression plants. Taken together, our results indicate that NF-YC1, NF-YC3, NF-YC4, and NF-YC9 function as transcriptional co-repressors by interacting with HDA15 to inhibit hypocotyl elongation in photomorphogenesis during the early seedling stage. Our findings highlight that NF-YCs can modulate plant development in response to environmental cues via epigenetic regulation. ? 2017 The Authorhistone deactylationhypocotyl elongationNF-YCphotomorphogenesis[SDGs]SDG2[SDGs]SDG13[SDGs]SDG15journal article10.1016/j.molp.2016.11.007https://www.scopus.com/inward/record.uri?eid=2-s2.0-85009460295&doi=10.1016%2fj.molp.2016.11.007&partnerID=40&md5=92f3d28a8f97a9f13bf1558983a73cc9278766422-s2.0-85009460295https://www.scopus.com/inward/record.uri?eid=2-s2.0-85009460295&doi=10.1016%2fj.molp.2016.11.007&partnerID=40&md5=92f3d28a8f97a9f13bf1558983a73cc9