KUO-LIONG CHIENWEI J. CHENHsu, Hsiu-ChingHsiu-ChingHsuTA-CHEN SUMING-FONG CHENLee, Yuan-TehYuan-TehLee2020-09-282020-09-282006-030009-8981https://www.scopus.com/inward/record.uri?eid=2-s2.0-32044452886&doi=10.1016%2fj.cca.2005.08.025&partnerID=40&md5=26c54b8f39d19e412b639b078e4821e4https://scholars.lib.ntu.edu.tw/handle/123456789/514886http://ntur.lib.ntu.edu.tw//handle/246246/197107http://ntur.lib.ntu.edu.tw//handle/246246/158803Background: Apolipoprotein (Apo) B is considered as a risk factor for atherosclerosis. Previous reports of segregation analyses on the mode of inheritance of Apo B were inconsistent because of heterogeneity in study population or elderly adult diseased probands. We performed complex segregation analysis of Apo B levels in the families of adolescents, systematically ascertained from junior high school students in a rural community in Taiwan. Results: There is a sex-specific influence in the variation of apo B levels. The mother-daughter (0.216), sister-sister (0.181), sister-brother (0.179) correlations were higher than father-son (0.206), brother-brother (0.002) or cross-sex correlations for the variation in Apo B levels. By the variance component model, the heritability estimate was 26.3 ± 6.7% (P < .0001) in Apo B levels. Commingling analysis indicated that a 2-component distribution was needed to account for Apo B variation. Segregation analysis using regressive models revealed that the best-fit model of Apo B was the model of major gene effect plus familial correlation. The gene frequency controlling high Apo B was 0.17, and 3 means of genotypes were 56.3, 54,2, and 117.2 mg/dl. Conclusion: Variations of Apo B levels in the normal range among adolescent families are controlled by major gene, and further identification of this gene locus will be mandatory. ? 2005 Elsevier B.V. All rights reserved.enApolipoprotein B; Community study; Heritability; Major genes[SDGs]SDG3apolipoprotein B; adolescent; adult; article; controlled study; correlation analysis; gene frequency; gene identification; gene locus; genetic analysis; genotype; heredity; heritability; human; inheritance; major clinical study; priority journal; segregation analysis; sex difference; Taiwan; Adolescent; Apolipoproteins B; Cohort Studies; Female; Humans; Male; Taiwanjournal article10.1016/j.cca.2005.08.025162338952-s2.0-32044452886