Cardiovascular and metabolic characters of KCNJ5 somatic mutations in primary aldosteronism

Chang, Yi-YaoYi-YaoChangBO-CHING LEEZHENG-WEI CHENCHENG-HSUAN TSAICHIN-CHEN CHANGCHE-WEI LIAOCHIEN-TING PANPeng, Kang-YungKang-YungPengChou, Chia-HungChia-HungChouCHING-CHU LUVIN-CENT WUCHI-SHENG HUNGYEN-HUNG LIN2023-04-182023-04-182023-03-061664-2392https://scholars.lib.ntu.edu.tw/handle/123456789/630249Primary aldosteronism (PA) is the leading cause of curable endocrine hypertension, which is associated with a higher risk of cardiovascular and metabolic insults compared to essential hypertension. Aldosterone-producing adenoma (APA) is a major cause of PA, which can be treated with adrenalectomy. Somatic mutations are the main pathogenesis of aldosterone overproduction in APA, of which KCNJ5 somatic mutations are most common, especially in Asian countries. This article aimed to review the literature on the impacts of KCNJ5 somatic mutations on systemic organ damage.enKCNJ5; adrenocortical adenoma; autonomous cortisol secretion (ACS); cardiovascular system; metabolic syndrome; somatic mutationCardiovascular and metabolic characters of KCNJ5 somatic mutations in primary aldosteronismjournal article10.3389/fendo.2023.1061704369506762-s2.0-85150513156WOS:000953454700001