HSIEN-LIANG HUANGChang, Chin-HaoChin-HaoChangCHIN-YING CHENJEN-KUEI PENGWang, Yu-TingYu-TingWangChen, Ching-YuChing-YuChenHsu, Chih-ChengChih-ChengHsuLee, Chung-ShengChung-ShengLeeJAW-SHIUN TSAI2021-11-172021-11-172020-07-240025-79741536-5964https://scholars.lib.ntu.edu.tw/handle/123456789/586933Geriatric frailty is associated with increased mortality and links to increased inflammatory activity. Vascular adhesion protein-1 (VAP-1) is important in inflammatory process. This study investigates the relationship between plasma VAP-1 level and frailty in older adults.The cross-sectional study recruited community dwelling older adults from a hospital-based comprehensive geriatric assessment program. The demographic data, Fried Frailty Index, metabolic and inflammatory parameters were assessed.A total of 151 participants (76 women, 50.3%) were included in the analysis, and the age (mean ±  standard deviation) was 77.1 ± 6.1 years. The mean plasma VAP-1 level (ng/mL) was significantly different (P = .029) among different frailty groups (346.3 ± 86.5 in the robust older adults, 371.6 ± 107.9 in the pre-frail older adults, and 416.6 ± 141.1 in the frail older adults). Multivariate ordered logistic regression analysis also demonstrated that plasma VAP-1 levels were positively associated with frailty severity (P = .039). Analysis of the frailty components with plasma VAP-1 levels showed that the elderly who had "exhaustion" (P = .016) or "weakness" (P = .025) tended to have higher plasma VAP-1 levels.The data support that VAP-1 might represent a potential plasma biomarker of frailty.en[SDGs]SDG3amine oxidase (copper containing); AOC3 protein, human; biological marker; cell adhesion molecule; aged; blood; classification; cross-sectional study; female; frail elderly; frailty; geriatric assessment; human; male; severity of illness index; very elderly; Aged; Aged, 80 and over; Amine Oxidase (Copper-Containing); Biomarkers; Cell Adhesion Molecules; Cross-Sectional Studies; Female; Frail Elderly; Frailty; Geriatric Assessment; Humans; Male; Severity of Illness Indexjournal article10.1097/MD.0000000000021192327916952-s2.0-85089525359https://scholars.lib.ntu.edu.tw/handle/123456789/517887