WEN-JENG LEEWang Y.H.Su C.T.SHYH-JYE CHENLi Y.W.TIEN-SHANG HUANG2020-08-052020-08-0520020894-9115https://scholars.lib.ntu.edu.tw/handle/123456789/511077Objective: Spinal cord injury in adult men may result in hypothalamicpituitary-adrenal axis dysfunction. Atrophy of adrenal glands was speculated in these patients. This study was undertaken to clarify the functional-anatomic correlation between adrenal volume and body surface area in subjects with spinal cord injury with impaired adrenal reserve. Design: Twenty male subjects with chronic spinal cord injury with impaired adrenal reserve were identified by adrenocorticotropic hormone stimulation test from a group of 42 subjects. All subjects with spinal cord injury and healthy volunteers underwent computed tomographic imaging with contiguous 3-mm section over adrenal glands for volumetric measurements. Ten pairs of subjects with spinal cord injury and controls with matched height and weight were included in the statistical analysis. Results: Significantly increased relative adrenal volumes were noted among subjects with chronic spinal cord injury and impaired adrenal reserve as compared with the body weight-matched and heightmatched control group. Conclusions: Increased relative adrenal volumes were found after chronic spinal cord injury. Hyperplasia of the zona glomerulosa may be the cause of increased relative adrenal volume after chronic spinal cord injury.[SDGs]SDG3Biological organs; Computerized tomography; Diseases; Hormones; Statistical methods; Volumetric analysis; Hormone stimulation tests; Medical applications; corticotropin; adrenal disease; article; body surface; cell hyperplasia; chronic disease; clinical article; computer assisted tomography; controlled study; correlation analysis; corticotropin test; functional anatomy; human; human tissue; hypothalamus hypophysis adrenal system; image analysis; male; organ weight; spinal cord injury; zona glomerulosa; Adrenal Glands; Adrenal Insufficiency; Adult; Humans; Male; Middle Aged; Organ Size; Pituitary-Adrenal Function Tests; Spinal Cord Injuries; Tomography, X-Ray Computedjournal article10.1097/00002060-200207000-00003121311732-s2.0-0036084596