國立臺灣大學醫學院外科杜永光Tu, Yong-KwangYong-KwangTu2006-07-262018-07-112006-07-262018-07-112005-07-31http://ntur.lib.ntu.edu.tw//handle/246246/24554Ideopathic normal pressure hydrocephalus is a common disease causing dementia, gait disturbance or incontinence. Cerebral ischemia at the periventricular region, aside from cerebrospinal fluid stagnation, was found to be a major pathophysiologic factor. Vascular endothelial cell growth factor and placenta growth factor was found to be elevated in the ventricular cerebrospinal fluid. Material and Methods Correlation was done on PlGF and VEGF with xenon-computed tomography study and albumin level or age of the patients. Results PlGF and VEGF are linearly corellated. Excluding age factor, ventricular PlGF was related to frontal part periventricular cerebral blood flow, yet not with ventricular albumin level. Ventricular albumin level was inversely related to the clinical good outcome after shunting (8 l vs 21μg/d). Conclusion Ongoing periventricular ischemia is one of the major factors in pathogenesis of INPH and ventricular PlGF can reflect that. However, stagnation of the cerebrospinal fluid outflow is probably more important factor.application/pdf117781 bytesapplication/pdfzh-TW國立臺灣大學醫學院外科normal pressure hydrocephaluscerebral ischemiaplacenta growth factorvascular endothelial growth factoralbuminreporthttp://ntur.lib.ntu.edu.tw/bitstream/246246/24554/1/932314B002246.pdf