CHUN-PIN CHIANGWu Y.-C.Wu Y.-H.JULIA YU-FONG CHANGYI-PING WANGSun A.2021-07-072021-07-0720200929-6646https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090127772&doi=10.1016%2fj.jfma.2020.08.035&partnerID=40&md5=c33739d90015460568685abb7f0e6f62https://scholars.lib.ntu.edu.tw/handle/123456789/570196Background/Purpose: Gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) are organ-specific autoantibodies. This study mainly assessed the frequencies of serum GPCA, TGA, and TMA positivities in burning mouth syndrome (BMS) patients. Methods: Serum GPCA, TGA, and TMA levels were measured in 884 BMS patients and in 442 age- and sex-matched healthy control subjects. Results: We found that 12.3%, 21.6%, and 22.7% of 884 BMS patients and 1.8%, 2.3%, and 2.9% of 442 healthy control subjects had the serum GPCA, TGA, and TMA positivities, respectively. BMS patients had significantly higher frequencies of GPCA, TGA, and TMA positivities than healthy control subjects (all P-values < 0.001). We also found that 20 (2.3%), 130 (14.7%), and 181 (20.5%) BMS patients and 3 (0.7%), 8 (1.8%), and 6 (1.4%) healthy control subjects had the presence of three (GPCA + TGA + TMA), two (GPCA + TGA, GPCA + TMA, or TGA + TMA), or one (GPCA only, TGA only, or TMA only) organ-specific autoantibody in their sera, respectively. Of 255 TGA/TMA-positive BMS patients whose serum thyroid-stimulating hormone (TSH) levels were measured, 87.8%, 5.1%, and 7.1% of these TGA/TMA-positive BMS patients had normal, lower, and higher serum TSH levels, respectively. Conclusion: Approximately 37.5% of 884 BMS patients have serum GPCA/TGA/TMA positivity. Moreover, 12.3%, 21.6%, and 22.7% of 884 BMS patients have the serum GPCA, TGA, and TMA positivities, respectively. Only 5.1% and 7.1% of TGA/TMA-positive BMS patients have hyperthyroidism and hypothyroidism, respectively. It needs further studies to know whether GPCA-positive BMS patients may finally become as having autoimmune atrophic gastritis. ? 2020 Formosan Medical Association[SDGs]SDG3autoantibody; microsome antibody; parietal cell antibody; thyroglobulin antibody; thyrotropin; autoantibody; adult; aged; antibody blood level; antibody specificity; Article; burning mouth syndrome; controlled study; evaluation study; female; human; human cell; major clinical study; male; stomach parietal cell; thyrotropin blood level; case control study; hyperthyroidism; stomach parietal cell; Autoantibodies; Burning Mouth Syndrome; Case-Control Studies; Humans; Hyperthyroidism; Parietal Cells, Gastricjournal article10.1016/j.jfma.2020.08.035328835682-s2.0-85090127772