Lin, Chun-ChingChun-ChingLinWu, Sue-JingSue-JingWuChang, Cheng-HsiungCheng-HsiungChangLEAN-TEIK HUANG2018-09-102018-09-102003-08https://www.scopus.com/pages/publications/0043013041?inwardThe antioxidant activities of hot water extracts (HWECC) and ethanol extracts (EECC) from the dry bark of Cinnamomum cassia Presl were evaluated in this study. Results showed that at 1.0 mg/mL, the ethanol extracts of C. cassia (96.30%) exhibited a greater inhibition than the α-tocopherol (93.74%) on FeCl2-ascorbic acid induced lipid peroxidation of rat liver homogenate in vitro. From 0.05 to 1.0 mg/mL, the EECC demonstrated the highest superoxide anions scavenging activity and the strongest anti-superoxide formation activity (p < 0.05). The same extract also showed an excellent antioxidant activity in enzymatic and nonenzymatic liver tissue oxidative systems. EECC revealed the strongest antioxidant activity followed by α-tocopherol and HWECC. Compared to α-tocopherol, the IC 50 values of EECC were found to be lower in thiobarbituric acid test (IC50 = 0.24 mg/mL vs 0.37 mg/mL), in cytochrome c test (IC 50 = 0.16 mg/mL vs 0.27 mg/mL) and in xanthine oxidase inhibition test (IC50 = 0.09 mg/mL vs 0.19 mg/mL). The present study concludes that EECC could be used as a good source of antioxidant in the dietary supplement.Antioxidant activityCinnamomum cassia PreslCytochrome cLipid peroxidationXanthine oxidase[SDGs]SDG6journal article10.1002/ptr.11902-s2.0-0043013041